1. NovaMin

2. What is NovaMin®? A “high-tech” active ingredient used in the
most innovative professional dental products.
Material Description
Technical Breakdown
NovaMin is a breakthrough
remineralization technology.
A tasteless white powder form.
NovaMin amplifies the natural
protective and repair mechanisms
for teeth and gums.
Extensively proven in clinical and
scientific studies at leading dental
schools around the world.
Comprised of calcium,
sodium, phosphorous
and silica, all natural
elements found in the
body
Chemical name is Calcium Sodium
Phosphosilicate
NovaMin is recognized as the only man
made ingredient that directly leads to the
formation of new tooth mineral
(HCA)

3. What Does NovaMin® Do? Repairs Surface Lesions Forms biomimetic HCA on
tooth dentin and enamel surface lesions
Reduces Sensitivity
Occludes dentin tubules: forms a protective biomimetic HCA layer.
Improves Gingival Health
Antimicrobial properties & Anti-inflammatory properties reduce gingivitis.

4. The NovaMin® Solution
Hard Tissue Benefits

5. The NovaMin® Solution
Soft Tissue Benefits

6. NovaMin: How it Starts
NovaMin is also called “calcium sodium phosphosilicate”.
It is made from elements naturally found in healthy teeth and bones:
Calcium ( ), Phosphorus ( ), Sodium ( ) and Silicon ( )

7. Step 1: pH Elevation
NovaMin reacts with saliva. Na+ ions release, elevating pH into the range essential for
HCA formation.
+H2O pH

8. Step 2: Mineral Release
Ca2+ and P5+ ions are released, saturating saliva with the ions needed for remineralization.
Ca2+
P5+

9. Step 3: Bacterial Kill
Na+ and Ca2+ ions overwhelm bacterial cells’ ability to regulate their water content, leading to lysis (cell death) of harmful bacteria in the mouth.
F. Nucleatum
S. Mutans
A.Naeslundii %
-99.99%
S. Sanguis % %

10. Demineralized lesions attract
Step 4: Crystal Building
Demineralized lesions attract
Ca2+ and P5+ ions, where they build new HCA crystal to remineralize the defect from the bottom up.
Enamel Crystal Prism
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)

11. Step 5: Time Release
NovaMin particles adhere to tooth surfaces for up to 7 days, continuing to release Na+, Ca2+, and P5+ ions to maintain elevated pH at the tooth surface and foster remineralization over time.
Enamel Crystal Prism
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)

12. Remineralization of Dentin & Enamel In-vitro Study – In-Situ Models
Surface Lesion
In-vitro
Surface Abrasion
In-Situ
Exposed Dentin
In-vitro
Before Treatment
After Treatment

13. NovaMin Product Focuses
Sensitivity:
Faster & better results
Addresses symptom, not cause.
Gingivitis:
Faster results
Less controversial ingredient
Root Caries/Remineralization:
Adult caries predominantly related to hyposalivation.
NovaMin directly addresses this etiology.

14. NovaMin & Sensitivity NovaMin Therapy Paste Results Clinical Results Vs. Placebo

15. NovaMin & Sensitivity NovaMin Therapy Paste Results Clinical Results Vs. Other Actives

16. NovaMin vs. Fluoride Remineralization of Dentin NTI-UCSF In-vitro Study – Dentin Remin/Demin Model
Product Tested Code
7.5% NM/1100 ppm MFP
7.5% NM
Company CR 5000 ppm NaF 3
Company CG 1.1 ppm MFP 4
0% NM/O ppm F

17. NovaMin and Gingivitis Anti-Microbial Properties

18. NovaMin and Gingivitis Pilot Clinical Study – Gingival Bleeding Index
-59%

19. NovaMin and Gingivitis Pilot Clinical Study – Plaque Index

20. NovaMin/Fluoride Enamel Remineralization In-vitro Study – Remin/Demin Model
Surface Lesion
~ 100µm
Sound Enamel
Sound Enamel
Sound Enamel
Demineralized Untreated Sample
Fluoride Dentifrice Treated Sample
NovaMin Dentifrice + F Treated Sample

21. NovaMin/Fluoride Enamel Remineralization In-vitro Study – Remin/Demin Model
-30%
-45%
p<0.001