1. CONVENTIONAL CANCER THERAPIES

3. Halsted’s Radical Mastectomy vs ‘Lumpectomy’

5. 3-D structure & schematic of p- glycoprotein

6. Examples: MethotrexateEg. Doxorubicin Eg. Cyclophosphoramide, Melphalan Eg. Vinblastine, paclitaxel

8. Newer Approaches to Cancer Therapy Incorporate Predictive Diagnosis Are Mechanism Based Designed for Selectivity

9. Figure 16.2 The Biology of Cancer (© Garland Science 2007)

10. Figure 16.4a The Biology of Cancer (© Garland Science 2007)

11. Figure 16.4b The Biology of Cancer (© Garland Science 2007)

12. Figure 16.5a The Biology of Cancer (© Garland Science 2007)

13. Figure 16.5b The Biology of Cancer (© Garland Science 2007)

14. Figure 16.5c The Biology of Cancer (© Garland Science 2007)

15. Figure 16.5d The Biology of Cancer (© Garland Science 2007)

16. Therapies Targeting nonTumor Cells

17. Table 13.3 The Biology of Cancer (© Garland Science 2007) Targeting the Angiogenic Switch

18. Tsp-1 Expression Induced by p53 Tsp-1 Expression Inhibited by Ras An Intrinsic Negative Regulator of Endothelial Cell Populations

20. VEGF-R Inhib. PDGF-R Inhib. Synergistic Inhibition of Angiogenesis by the Combination of a Pericyte Inhibitor and an Endothelial Cell Inhibitor

21. Figure 13.48a, b The Biology of Cancer (© Garland Science 2007) Radiation Can Have a Greater Effect on Cells of the Microvasculature Than on Tumor Cells Bone marrow origin of microvasculature cells

22. Figure 13.49 The Biology of Cancer (© Garland Science 2007)