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another example: Carbonic Anhydrase
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Zn
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Active site in -carbonic anhydrase
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Active site and mechanism in -carbonic anhydrase deprotonation Nucleophilic attack on CO2 Charge stabilization START :B(GLU) H + :B(GLU)
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CO 2 --> [CO 3 ] 2- CO 2 --> glucose CO 2 <-- [CO 3 ] 2- glucose --> CO 2 Carbonic Anhydrase is critically important in global C- cycle
![CO 2 --> [CO 3 ] 2- CO 2 --> glucose CO 2 <-- [CO 3 ] 2- glucose --> CO 2 Carbonic Anhydrase is critically important in global C- cycle](http://images.slideplayer.com/25/8060707/slides/slide_5.jpg "CO 2 --> [CO 3 ] 2- CO 2 --> glucose CO 2 <-- [CO 3 ] 2- glucose --> CO 2 Carbonic Anhydrase is critically important in global C- cycle")
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CO 2 --> [CO 3 ] 2- CO 2 <-- [CO 3 ] 2- Carbonic Anhydrase important in global C- cycle because catalyzes both directions! Phytoplankton do this: HCO 3 - CO 2 Diatoms do this: CO 2 HCO 3 - CA importance means these critters are growth limited: when there’s too little Zn, can use Cd and Co!!
![CO 2 --> [CO 3 ] 2- CO 2 <-- [CO 3 ] 2- Carbonic Anhydrase important in global C- cycle because catalyzes both directions.](http://images.slideplayer.com/25/8060707/slides/slide_6.jpg "Phytoplankton do this: HCO 3 - CO 2 Diatoms do this: CO 2 HCO 3 - CA importance means these critters are growth limited: when there’s too little Zn, can use Cd and Co!!.")
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Acid/base chemisty in catalysis of Mo enzymes: oxidation of SO 3 2- See in this step how Mo charge affects H2O acidity ditto
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