1. 1 Why is Photostability Important?

2. 2 Biggest Innovation in UVA Protection has Been the Invention of Avobenzone Avobenzone provides broad spectrum beyond 370 nm 290 Wavelength (nm) 2.5 1.5 1 0.5 0 2 310330350370390 Absorbance With avobenzone With oxybenzone Data on file, Johnson & Johnson Neutrogena.

3. 3 An Example of Avobenzone Photoinstability in a Sunscreen Formulation Wavelength (nm) Absorbance 290310330350370390 Static SPF 10 J 20 J 50 J 2.0 1.8 1.6 1.4 1.2 1.0 0.6 0.4 0.2 0 0.8 Data on file, Johnson & Johnson Neutrogena.

4. 4 Why is Photostability Important? Photostable and non-photostable spf products have the same protection up to their SPF value, but protection after first MED is very different

5. 5 How Can You Tell Which Ones Are Photostable? Currently, there is no uniform test method or communication device on products to indicate photostability of products or extent of UVA protection

6. 6 Helioplex ™ Technology

7. 7 What Comprises Helioplex ™ Technology? Photostable UVA –Contains avobenzone—provides broad UVA protection –Contains diethylhexyl 2,6-naphthalate (DEHN)— an avobenzone stabilizer –Contains benzophenone (oxybenzone, sulisobenzone, or dioxybenzone)—stabilizes avobenzone and adds UVA protection Added SPF drivers – Conventional UV filters to build SPF Data on file, Johnson & Johnson Neutrogena.

8. 8 Mechanism of Action of Helioplex ™ UV

9. 9 Mechanism of Action of Helioplex ™ UV DEHN UV DEHN UV DEHN UV DEHN

10. 10 Ultraviolet Photography demonstrates the red fluorescence of Helioplex ® Photograph courtesy of Darrell Rigel, MD

11. 11 Neutrogena Now Offers Broad-Spectrum Protection That Is Photostable Wavelength (nm) Neutrogena Ultra Sheer SPF 50+ With Helioplex™ 1.8 Absorbance 290310330350370390 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0 290310330350370390 1.8 1.6 1.4 1.0 1.2 0.8 0.6 0.4 0 0.2 0 J 10 J 20 J 30 J 50 J Nonphotostable Sunscreen Data on file, Johnson & Johnson Neutrogena.

12. 12 Photostable in Real Sunlight Neutrogena Ultra Sheer SPF 50+ holds up under sunlight Baseline 1.5 hours of sun 0 0.5 1.0 1.5 2.0 290310330350370390 Wavelength (nm) Absorbance Data on file, Johnson & Johnson Neutrogena.

13. 13 Photostable in Real Sunlight Neutrogena Ultra Sheer SPF 50+: PFA 12.1 20% ZnO SPF 4: PFA 4 9% TiO 2 SPF 30: PFA 4.5 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 290310330350370390 Wavelength (nm) Absorbance Data on file, Johnson & Johnson Neutrogena.

14. 14 Photostability of Helioplex ™ Compared With Anthelios SPF 60+ With Mexoryl ® Data on file, Johnson & Johnson Neutrogena. COLIPA n = 5 avg In Vitro Photostability (COLIPA Method) % Loss After 50 J Simulated Exposure 40 20 0 Anthelios XL 60+ –15% –39% Neutrogena Ultra Sheer SPF 50+ With Helioplex ™ % Loss

15. 15 Photostable Even Under Direct Tropical Sun Exposure*

16. 16 Helioplex ™ technology offers a step change in protection Helioplex ™ technology offers exceptional and photostable UVA protection – PA +++! –PFA protection values for Helioplex products exceed 20 (PA+++ only requires PFA = 8) Comparable protection to Mexoryl  Anthelios XL 60 technology with better photostability

17. 17 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Results

18. 18 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Conclusions Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif. Percent Agreement Subject Self-Perception Efficacy and Aesthetics 7580859095100 Lengthens time outdoors Weightless feeling Is not greasy/oily/tacky Absorbs quickly/evenly Does not sting Is gentle Overall rating (excellent-good)

19. 19 PLE Protection by Ultra Sheer SPF 50+ With Helioplex ™ : Conclusions Complete inhibition of PLE by Ultra Sheer SPF 50+ with Helioplex ™ The aesthetics of Ultra Sheer SPF 50+ with Helioplex ™ was favorably rated by users with PLE; this may enhance compliance with use Leyden J, et al. Multi-center evaluation of protective benefits of a photostable UVA/UVB sunscreen for polymorphic light eruption. Poster presentation at: American Academy of Dermatology 64th Annual Meeting; March 3-7, 2006; San Francisco, Calif.

20. 20 Neutrogena Helioplex Sunscreens Does not leave a film/residue Is not tacky Is not sticky Is not greasy Leaves a velvety skin feel Leaves the skin feeling nourished Data on file, Johnson & Johnson Neutrogena.

21. 21 Sunscreen With Helioplex ™ : Ultra Sheer Aesthetics Unsurpassed Protection Superior Aesthetics and Skinfeel Outstanding Value Dermatologists Preferred for themselves and their families