1. Beginning of the chapter Gluten intolerance and Genetics (Gluten Sensor) 45

2. SENSORS GLUTEN SENSOR Celiac disease / Gluten Intolerance

3. SENSORS GLUTEN SENSOR Gluten (Wheat protein) Incorrect programming of the immune system (it fights against gluten) digestive problems lactose intolerance 9x higher ENT tumor risk 80x higher lymphatic tumor risk On average, 11 years until diagnosis 12% of the untreated cases are fatal Gluten-free diet >>>Complete freedom from symptoms >>>Normalization of the other (tumor) risks

4. GLUTEN INTOLERANCE Receptors and infections Bacteria Receptor genes Bacteria The receptor presents bacterial proteins Bacteria is absorbed The bacteria is broken up The receptor is built and the bacterial proteins are integrated T-cell APC-cell ALARM!!! DQ-A1 DQ-B1

5. GLUTEN INTOLERANCE Receptors and infections Receptor gene Wheat protein (gluten) is absorbed Proteins are broken up The receptor cannot integrate gluten APC-cell T-cell Everything OK! DQ-A1 DQ-B1

6. GLUTEN INTOLERANCE Receptors and infections Receptor gene Wheat protein (gluten) is absorbed Proteins are broken up Gluten is integrated into the receptor APC-cell The receptor contains Gluten T-cell ALARM!!! DQ-A1 DQ-B1

7. GLUTEN INTOLERANCE Receptors and infections What can we find out from the genetic analysis? Negative -> The probability of gluten intolerance = ~0% Positive -> The probability of gluten intolerance = up to 40% Pay attention to symptoms > immediate, correct diagnosis Gluten Free Diet > absolute freedom from symptoms

8. GLUTEN INTOLERANCE Counselling example EARLY DETECTION 1)Pay attention to the symptoms when eating gluten containing products DIETARY ADJUSTMENTS 1)Avoid gluten containing food Nutrition Sensor can help

9. End of the chapter Gluten intolerance and genetics (Gluten Sensor) 45