1. Functional Neuroanatomy of Body Shape Perception in Healthy and Eating-Disordered Women Uher et al. Vivian Kwan

2. Introduction Anorexia Nervosa (AN) and Bulimia Nervosa (BN) patients view their bodies unrealistically Dysfunction in body image processing Related Brain Areas: Extrastriate body area (EBA) –lateral occipitotemporal cortex Right parietal cortex

3. Research Question: How will the brain responses to body shapes differ in healthy vs. eating disordered women? Hypothesis: Pictures of body shapes will elicit different brain responses in healthy vs. AN and BN patients

4. Methods participants: 8 Bulimia Nervosa 13 Anorexia Nervosa 18 Healthy All women procedure: FMRI scanner - mirror on head coil reflected the pictures off of a projection screen stimulus: pictures shown for 2.5 seconds followed by blank screen for 0.5 seconds

5. Results Compared to healthy women, women with eating disorders had significantly lower activation of: - occipitotemporal cortex (includes EBA) - parietal cortex When looking at body shape pictures

6. Discussion Analysis of results: - underactivity of this network may explain distorted and unrealistic perceptions of their own body Limitations: - Y causes X - line drawings instead of real life images - fluctuations in body image in patients - medical comorbidity (eg. Depression, OCD)

7. Implications Insight into how eating disorders may be developed -development of drugs to treat eating disorders

8. Future Directions Males More thorough participant screening (for comorbidity & stage of illness/state of body image)

9. What you Should Study for Midterm key finding: body shape processing different in healthy vs eating-disordered women - BN/AN patients had lower activation in occipitotermporal cortex and the parietal cortex Interpretation: this underactivity may explain distorted of patient’s own perception of their bodies Implications: insight into what causes eating disorders Main limitation: patient sample- medical comorbidity and changing body image

10. Opinion on the Paper The Good Captivating intro Concise Clear graphs Interesting study has pictures of brains ( !) The Bad Too much detail Discussion not very organized All in All… Good: Made a complex study understandable

11. Uher, R., Murphy, T., Friederich, H., Dalgleish, T., Brammer, M., Giampietro, V., Phillips, M., Andrew, C., Ng, V., Williams, S., Campbell, I., and Treasure, J. (2005). Functional neuroanatomy of body shape perception in healthy and eating-disordered women, Biological Psychiatry, 58 (12), 990-997.

12. Thank You, Questions?