1. AFAMS Intro to ATC Drug Codes (Dari) EO 003.01 Part 16

2. AFAMS Importance of Lesson (Dari) Pharmacy technicians are required to have a basic understanding of drug classification in order to understand where and how a given drug works in the body as well as its therapeutic use. AFAMS Insert Dari

3. AFAMS Overview of Lesson (Dari) Define ATC Role of the World Health Organization (WHO) Organization of the ATC Drug Codes Example of Drug Classification What a Pharmacy Technician needs to know 1 st level of classification 2 nd level of classification 3 rd level of classification 4 th level of classification 5 th level of classification AFAMS Insert Dari

4. AFAMS What does ATC mean? (Insert Dari) ATC = Anatomical Therapeutic Drug Classificaiton System Active substances are divided into different groups according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties. Active substance = ingredient in the medication that causes effect (i.e. lowers blood pressure). Insert Dari

5. AFAMS Role of the World Health Organization (WHO) (Insert Dari) The World Health Organization (WHO) publishes guidelines for ATC drug classification and DDD assignment. DDD assignment = Defined Daily Dose Updates to the document occur yearly and can be found on the WHO website. Insert Dari

6. AFAMS Organization of the ATC System (Insert Dari) Drugs are classified at 5 different levels: 1 st level – anatomical site of action where it acts in the body 2 nd level –therapeutic subgroup what it is used for 3 rd / 4 th level – pharmacologic subgroup or a further therapeutic class or chemical class type of drug or a more specified use for the drug or a chemical class of drug 5 th level – chemical substance the name of the actual drug Insert Dari

7. AFAMS Example: Sucralfate (Insert Dari)

8. AFAMS How is Sucralfate Classified? (Insert Dari) 1 st level - A (alimentary tract and metabolism) 2 nd level – A02 drugs for acid related disorders 3 rd level – A02B drugs for peptic ulcer disease and gastroesophageal reflux disease (GERD) 4 th level – A02BX other drugs for peptic ulcer disease and gastroesophageal reflux disease (GERD) 5 th level – A02BX02 sucralfate 1 st level – anatomical site of action where it acts in the body 2 nd level –therapeutic subgroup what it is used for 3 rd / 4 th level – pharmacologic subgroup or a further therapeutic class or chemical class type of drug or a more specified use for the drug or a chemical class of drug 5 th level – chemical substance the name of the actual drug

9. AFAMS Insert Dari

10. AFAMS What do I need to know as a Pharmacy Technician? (Insert Dari) It is NOT necessary for a pharmacy technician to know all 5 levels of classification for a given drug (i.e. metformin = A10BA02). What is important is to understand are the following: Where the drug acts in the body Therapeutic use (indication) Basic pharmacological class The ATC system is a useful tool to remember this information. Insert Dari

11. AFAMS 1 st Level of Classification : Anatomical Site of Action (Insert Dari)  Alimentary Tract and Metabolism (A)  Blood and blood forming agents (B)  Cardiovascular (C)  Dermatologicals (D)  Genitourinary system and sex hormones (G)  Systemic hormonal preparations, excl. Sex hormones and insulin (H)  Antiinfectives for Systemic Use (J)  Antineoplastics and Immunomodulators (L)  Musculoskeletal System (M)  Nervous System (N)  Antiparasitic products, insecticides and repellents (P)  Respiratory System (R)  Sensory Organs (S)  Various (V) Insert Dari

12. AFAMS Insert Dari

13. AFAMS 2 nd Level of Classification : Therapeutic Use Example From: Alimentary Tract and Metabolism (A) A01 – Stomatological preparations A02 – Drugs for acid related disorders A03 – Drugs for functional Gastrointestinal Disorders A04 – Antiemetic and antinauseants A05 – Bile and Liver Therapy A06 – Drugs for constipation A07 – Anti-diarrheals, Anti-inflammatories and Antiinfectives for the gastrointestinal tract A08 – Anti-obesity preparations (excl diet products) A09 – Digestives (incl enzymes) A10 – Drugs used in diabetes A11 – Vitamins A12 – Minerals A13 – Tonics A14 – Anabolic Steroids for Systemic Use A15 – Appetite Suppressants A16 - Other

14. AFAMS Insert Dari

15. AFAMS 3 rd Level of Organization : Further Therapeutic Class or Pharmacologic Class Example From: A02 Drugs Used in Acid Disease A02A – Antacids A02B – Drugs for Peptic Acid Disease and Gastroesophageal Reflux Disease A02X - Other Drugs for Acid Related Disorders

16. AFAMS Insert Dari

17. AFAMS 4 th Level of Organization: Pharmacologic Class or Chemical Class Example From: A02B – Drugs for Peptic Acid Disease and Gastroesophageal Reflux Disease A02BA : H2-receptor antagonists A02BB : Prostaglandins A02BC : Proton pump inhibitors A02BD : Combinations for eradication of Helicobacter pylori A02BE : Other drugs for peptic ulcer and gastro-oesophageal reflux disease

18. AFAMS Insert Dari

19. AFAMS 5 th Level of Classification : Name of Substance Example From : A02BE : Other drugs for peptic ulcer and gastro-oesophageal reflux disease sucralfate Note: The ATC System only uses generic names of medication (this topic will be covered in greater detail in EO 003.03.

20. AFAMS Insert Dari

21. AFAMS Questions? (Insert Dari)

22. AFAMS In-class Assignment (Insert Dari)

23. AFAMS 1. What does ATC mean? (Insert Dari) A) Anatomical Taxonomy Classification System B) Anatomical Therapeutic Classification System C)Anatomical Theory Classification System D)Appropriate Therapeutic Classification System Insert Dari

24. AFAMS 1. Answer: What does ATC mean? (Insert Dari) A) Anatomical Taxonomy Classification System B) Anatomical Therapeutic Classification System C)Anatomical Theory Classification System D)Appropriate Therapeutic Classification System Insert Dari

25. AFAMS 2. How many levels of classification are there in the ATC system? (Insert Dari) A)4 B)3 C)5 D)2 Insert Dari

26. AFAMS 2. Answer: How many levels of classification are there in the ATC system? (Insert Dari) A)4 B)3 C)5 D)2 Insert Dari

27. AFAMS 3. Answer: The ATC code for sucralfate is A02BX02, what does the ‘A’ indicate? (Insert Dari) A)The anatomical site of action B)The therapeutic use of the drug C)The chemical class of the drug D)The pharmacological class of the drug Insert Dari

28. AFAMS 3. The ATC code for sucralfate is A02BX02, what does the ‘A’ indicate? (Insert Dari) A)The anatomical site of action B)The therapeutic use of the drug C)The chemical class of the drug D)The pharmacological class of the drug Insert Dari

29. AFAMS 4. The ATC code for metformin is A10BA02, what does ‘10’ indicate? (Insert Dari) Insert Dari A)The anatomical site of action B)The therapeutic use of the drug C)The chemical class of the drug D)The pharmacological class of the drug

30. AFAMS 4. Answer: The ATC code for metformin is A10BA02, what does ‘10’ indicate? (Insert Dari) Insert Dari A)The anatomical site of action B)The therapeutic use of the drug C)The chemical class of the drug D)The pharmacological class of the drug

31. AFAMS 5. The 3 rd and 4 th levels of classification indicate what? (Insert Dari) A)A further therapeutic class B)A chemical class C)A pharmacologic class D)All of the above Insert Dari

32. AFAMS 5. Answer: The 3 rd and 4 th levels of classification indicate what? (Insert Dari) A)A further therapeutic class B)A chemical class C)A pharmacologic class D)All of the above Insert Dari