1. Lesson 3 Slide 3.1 What might cause this disease?

2. Lesson 3 Slide 3.2 Build up of fatty deposits on under skin and in arteries Fatty Deposit Coronary Artery: a heart artery Fatty Deposit Knees and Fingers Very high cholesterol in blood Chest pain and heart attacks at a young age Familial Hypercholesterolemia (FH) Symptoms

3. Lesson 3 Slide 3.3 Fatty Deposit Fatty Deposits In Coronary Artery Cross Section of Coronary Artery Artery wall injured by toxins from smoking, high blood pressure Arteries harden and narrow due to fat accumulation Blood flow is reduced Oxygen supply to heart reduced Can cause chest pain heart attack or death in severe cases Normal Tear in artery wall Fatty deposits made in artery wall Narrowed artery blocked by blood clot Why People With FH Have Heart Attacks

4. Lesson 3 Slide 3.4 nucleus cell inside cell outside cell Cholesterol in LDL LDL Receptor Plasma Membrane Takes LDL into cell cholesterol Low density lipoprotein (LDL) Receptor

5. Lesson 3 Slide 3.5 Cell Tissue Liver (organ) DNA Nucleus LDL Receptor Where is DNA located?

6. Lesson 3 Slide 3.6 From a cell not dividing UNPACKED From a just divided cell PACKED nucleus Condensed package Chromosomes

7. Lesson 3 Slide 3.7 double helix nucleus Base Pairs chromosome Chromosomes are Single Pieces of DNA

8. Lesson 3 Slide 3.8 From DNA sequence to Protein overview From RNA sequence to protein - more detail http://www-class.unl.edu/biochem/gp2/m_biology/animation/gene/gene_a1.html From DNA to RNA - more detail How do genes provide instructions for building proteins?

9. Lesson 3 Slide 3.9 RNA amino acid Coding Amino Acids

10. Lesson 3 Slide 3.10 Key to Toobers Blue=positive charge (+) K, R, H Red=negative charge (-) D, E Yellow=hydrophobic A, V, L, I, P, M, F, W Green=hydrophilic G, S, T, N, Q, Y White = cysteine C

11. Lesson 3 Slide 3.11 CYTOPLASM NUCLEUS Summary: DNA to protein

12. Lesson 3 Slide 3.12 View slide to play movie Click for another representation of DNA From Cells to DNA movie