1. ISBSTP Instructions for Authoring and Submitting Case of the Month ROLLING SUBMISSION PROCESS: On a rolling submission basis, cases illustrating the practice of bone and soft tissue pathology will be presented. Deadlines for first submission will be quarterly: Please submit your case as soon as possible. First Deadline for Case Submission: November 1, 2015 All cases will be reviewed by two members of the Case of the Month Committee, comprised of the Members-at-Large for this society. Case of the Month will be available by the first weekday of each month on the ISBSTP website, starting January 2015 IMPORTANT: This is an educational website and all included photographs may be used by the case of the month author(s) for publication elsewhere. 1

2. PLEASE EMAIL POWERPOINT CASE SUBMISSION WITH SUBJECT LINE: “ISBSTP CASE OF THE MONTH [SUBMITTER INITIALS]” to the following EMAIL address: jcfsmd@gmail.com 2

3. Author(s) Information Name (s): State, Country: Email: 3

4. Please include age, sex, anatomic location (may add depth), size, and may add brief relevant clinical information Clinical History 4

5. 5 PICTURE 1 (RADIOLOGIC IMAGING): [In JPG or TIFF format, if available attach at least one best radiologic image for bone cases, any available gross photograph, up to 6 microscopic pictures, immunohistochemical pictures, and/or molecular figures, may be added, numbered with same subject line, all photographs must be de-identified with no patient or surgical number information. One can arrange the photographs together on one page, how these should be displayed]

6. 6 PICTURE 2 (GROSS PATHOLOGY):

7. 7 PICTURE 3 (MICROPHOTOGRAPH):

8. 8 PICTURE 4 (MICROPHOTOGRAPH):

9. 9 PICTURE 5 (IMMUNOHISTOCHEMISTRY):

10. 10 PICTURE 6 (IMMUNOHISTOCHEMISTRY):

11. 11 PICTURE 7 (MOLECULAR):

12. 12 PICTURE 8 (MOLECULAR):

13. Question #1 What is your diagnosis? Answers: Please put in alphabetical order realistic differential diagnosis including actual diagnosis. Keep length of answer about the same. If images are desired, place them on the page appropriately. Be sure to denote the correct answer. A. B. C. D. E. (Correct Answer) 13

14. Question #1: Correct Answer (whatever is the correct letter) Correct Answer (to be revealed after click on answer above): (give letter and diagnosis) is correct. (put in entire discussion including differential diagnosis, with references Brief discussion (in sentence format, to be revealed with the diagnosis, less than 400 words, Microsoft Word, Times New Roman font, type size 11, single space, to include the following:) Include brief discussion of clinical, radiologic, gross, microscopic, immunophenotypic, and molecular features. 14

15. Question #1 Feedback A.Not Correct. (Give one sentence reason. Do not give away the answer. They can try again) B.Not Correct. (Give one sentence reason) C.Not Correct. (Give one sentence reason) D.Not Correct. (Give one sentence reason) These responses are revealed individually when the user submits his answer. 15

16. Question #2 What type of ancillary studies are helpful for diagnosis, prognosis, and/or treatment? Question tests user on their read of above paragraph. Be sure to denote correct answer. A.Imaging B.Immunohistochemistry C.Immunohistochemistry and Molecular D.Molecular E.None or Other (Correct Answer) 16

17. Question #2 Feedback, correct (whatever letter) Letter, answer and discussion of details More than one can be correct. Few sentence discussion of IHC and molecular and imaging in this case. These responses are revealed when the user submits his answer. 17 (linked) Correct Answer: (Letter, answer and discussion of details, more than one can be correct, few sentence discussion of IHC and molecular and imaging in this case.)

18. Question #2 Feedback These responses are revealed when the user submits his answer. Feedback Text (Letter). This is incorrect. (Give brief reason, this is if they give an incorrect answer above). Feedback Text (Letter). This is incorrect. (Give brief reason). Feedback Text (Letter). This is incorrect. (Give brief reason). Feedback Text (Letter). This is incorrect. (Give brief reason). 18

19. Question #3 What is the best classification and treatment? Be sure to denote correct answer. A.Reactive B.Benign; excision C.Intermediate, locally aggressive; wide excision D.Intermediate, rarely metastasizing; wide excision E.Low grade malignant, surgery with or without adjuvant radiation F.High grade malignant, surgery with or without adjuvant radiation and/or chemotherapy G.High Grade Malignant, targeted therapy (Correct Answer) 19

20. Question #3 Feedback, correct (linked) Correct Answer: (Letter. Brief Reason) These responses are revealed when the user submits his answer. 20

21. Question #3 Feedback Letter, answer and discussion of details These responses are revealed when the user submits his answer. Feedback Text (Letter): This is incorrect. (Brief Reason, this is if they push the wrong letter above) Feedback Text (Letter): This is incorrect. (Reason) 21

22. Give a brief differential diagnosis: 22

23. State why this is a great case: 23

24. References (List up to 4 references): Reference 1 Reference 2 Reference 3 Reference 4 24

25. Additional Credits, Suggested Reading, Other Optional page. 25

26. List of Submitted Image File Names Question #File NameIndicate template slide # where image is to appear) 26 Acceptable Formats:.jpg.tiff