1. Review of the PTR-ToF technique

2. Detection limit: < 1 pptv Sensitivity: > 1000 (up to 2500) cps/ppbv (Benzene) Mass Resolution: > 6000 (up to 10,000)

3. Mass resolution> 6000 (up to 10,000) m/Δm (FWHM) Response time100 ms Sensitivity> 1000 (up to 2500) cps/ppbv for m/z 79 @ Resolution > 6000 > 2000 (up to 4500) cps/ppbv for m/z 181 @ Resolution > 6000 Detection limits (LoD)< 10 pptv (averaged over 60 sec) m/z 79 < 1 pptv (averaged over 60 sec) for m/z 181 Linearity range1 pptv - 0,5 ppmv Pulse frequencyup to 200 kHz Adjustable flow50 -1000 sccm Inlet system heating rangeup to 180°C (2nd inlet system and other inlet options on request) Reaction chamber heating range40 - 120°C Dimensions (w x h x d)60x110x80 cm Weight< 175 kg Power requirements100-115/200-230 V, max 1500 W Technical Specifications:

4. Uses of the device for breath Real-Time Breath Analysis with PTR-MS Breath-Markers for Smoking Biomarkers for Lung-Cancer Pharmacokinetics Monitoring metabolic processes

5. Projects NameBAMOD AcronymBreath-gas analysis for molecular-oriented detection of minimal diseases Type of fundingEU Project, 6th Framework Program (FP6) Duration2004 - 2009 Project Websitehttp://eu-proposal.voc-research.at/ Kohl, I., et al., "First observation of a potential non-invasive breath gas biomarker for kidney function.", J Breath Res, vol. 7, no. 1: Ionimed Analytik GmbH, Eduard Bodem Gasse 3, A-6020 Innsbruck, Austria., pp. 017110, Mar, 2013. LINKLINK Herbig, J.., et al., "Breath Analysis with PTR-MS: More breath markers for lung cancer", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 31-33, 2011. LINKLINK

6. Another project development of nano-sensors for medical breath analysis. PTR-MS technology complements the sensor information and develops a novel calibration device for sensor characterization. The acronym LCAOS is derived from Lung Cancer detection with an Artificial Olfactory System. In this project novel types of sensors, based on chemically-sensitive field effect transistors (FETs), will be developed and employed for breath analysis. The goal is a cheap and hand- held device for the detection of volatile biomarkers for lung cancer in breath. PTR-MS is used in the project to identify breath markers, with the aim to develop smaller, sensor based systems for these markers. We contribute our expertise in breath analysis and PTR-MS technology. PTR-MS technology

7. Different methods

8. Problematic concentration data due to binary bonding site Gas detection on chip Might be good for one use - disposable

9. More info http://www.ionicon.com/applicationshowcase s/medical-applications