1. International Regulome Consortium Toronto – October 29, 2005 Cindy Bell, VP, National Genomics Program Genome Canada

2. Genome Canada – Organizational Structure Genome Centres Board of Directors Science and Industry Advisory Committee Prairie Ontario Québec Atlantic B.C. Genome Canada (President & CEO) Functional Genomics Genotyping Sequencing Proteomics BioinformaticsAutomation GELS

3. Funding and Investments Genome Canada launch 2000200120022003200420052006 Comp I projects begin Comp II projects begin Applied Health projects begin Comp III projects begin Comp I & Comp II projects end Federal Budget 2000 $160 M Federal Budget 2001 $140 M Federal Budget 2003 $75 M Federal Budget 2004 $60 M Federal Budget 2005 $165 M

4. Genome Canada = $600 million Partner Funding = $600 million Total Funding = $1,200 million Sectors Genome Canada Portfolio (September 2005) B.C.PrairieOntarioQuebecAtlanticTotal Agriculture 24118 Bioinformatics 11 Environment 1214 Fisheries 224 Forestry 21216 GE3LS 22329 Health 18420 365 Technology Development 235 Platforms 5121110 Total Projects 321333268112 50 Genome Canada-funded projects are expected to end by March 31, 2006.

5. Why International? Leverage core Strengths Complementary Science Facilities Resources Funding Visibility / Branding Recruitment Emerging Opportunities

6. National Genomics Strategy International Partners Sweden U.K. Denmark SpainNorway Genome Canada Genome Quebec Genome Atlantic Genome Ontario Genome B.C. Nether- lands Estonia Genome Prairie USA Australia

7. International Projects – Mechanisms for Support Investigator Initiated (regular application to Genome Canada with an international partner) Bilateral Competition (e.g., Genome Canada/Geñoma Espana) Community Led (e.g., Bovine project) International Consortium Initiative (e.g., SGC) September 2005

8. USA30 % UK25 % Japan25 % China10% Canada10 % The HapMap will describe patterns of DNA sequence variation. It will be a key resource to find genes and responses to drugs.

9. Title High Throughput Mammalian Functional Analysis for the Discovery of Novel Determinants of Human Disease Goals The International Knock-out Mouse Project is a worldwide effort to generate knock-out mutations in every gene in the mouse genome Budget (CDN$)$23.6 million (maximum approved budget) Partners Affiliated with the European Conditional Mouse Mutagenesis Project Project Leaders Geoff Hicks, University of Manitoba Janet Rossant, Mount Sinai Hospital North American Conditional Mouse Mutagenesis Project

10. ProjectLocations CanadaSpain Flatfish Genomics (Halibut & Sole) IMB, Halifax IRTA, Barcelona $ 2.0 M$ 3.0 M Grapevine Genomics (Wine & Table grapes) UBC, Vancouver CSI, Madrid $ 3.1 M Neurodevelopment DisordersUniversity of Toronto CRG, Barcelona $ 2.6 M TOTALS$ 7.7 M$8.7 M Genome Canada Genoma España Joint Projects

11. Total Budget$53 million US Funding Partners NIH’s NHGRI $25 million USDA 11 million State of Texas 10 million Genome Canada 5 million Australia & New Zealand 2 million Sequencing Efforts Genomic DNA sequencing – Baylor College of Medicine Gene sequencing – Genome BC platform at BC Cancer Agency & U. of Alberta Bovine Genome Sequencing Project (Bos taurus)

12. International Consortium Initiative Designed for unique international projects with potential for significant impact on Canadian science Project must be led by a Canadian researcher and request a minimum of $50 million over 3 years Genome Canada will pay up to 25% of total costs Workshop funds available to help develop consortia One proposal and five workshops have been approved to date September 2005

13. Goals  Determine the three-dimensional structure of more than 350 human proteins  Encourage the development of new and improved drugs LocationUniv. of Toronto (lead) and Univ. of Oxford CEOAled Edwards, University of Toronto Funding (CAN$ over 3 yrs) Wellcome Trust $46 M Nordic Node $15 M Genome Canada $15 M ORDCF $15 M OIT $ 7 M GlaxoSmithKlein $ 6 M CIHR $ 6 M TOTAL= $110 M Features Largest health research project funded in Canada Protein structures will be in public domain Canada-UK Structural Genomics Consortium

14. Canada Finland, Sweden, Norway, Denmark, Netherlands, UK Estonia United Kingdom Vision: Foster international harmonization for public projects in population genomics Public Population Project in Genomics

15. 150 rue Metcalfe Street, Suite 2100 Ottawa, Ontario CANADA K2P 1P1 Tel: (613)751-4460 Fax: (613)751-4474 info@genomecanada.ca www.genomecanada.ca