1. 3/30 Warm Up 1.Where in the respiratory system does gas exchange take place? 2.What is Pulmonary Ventilation? 3.What are the 4 “events of respiration”?

2. Respiratory Physiology II Ch. 13c

3. Events of Respiration Pulmonary Ventilation External Respiration Respiratory Gas Transport Internal Respiration

4. External Respiration Slide 13.32a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Oxygen movement into the blood  The alveoli always has more oxygen than the blood  Oxygen moves by diffusion towards the area of lower concentration  Pulmonary capillary blood gains oxygen

5. External Respiration Slide 13.32b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Carbon dioxide movement out of the blood  Blood returning from tissues has higher concentrations of carbon dioxide than air in the alveoli  Carbon Dioxide diffuses out of pulmonary capillary blood in to the alveoli to be released from the lungs  Blood leaving the lungs is oxygen-rich and carbon dioxide-poor

6. Gas Transport in the Blood Slide 13.33a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Oxygen transport in the blood  Inside red blood cells attached to hemoglobin (oxyhemoglobin [HbO 2 ])  A small amount is carried dissolved in the plasma

7. Gas Transport in the Blood Slide 13.33b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Carbon dioxide transport in the blood  Most is transported in the plasma as bicarbonate ion (HCO 3 – )  A small amount is carried inside red blood cells on hemoglobin, but at different binding sites than those of oxygen

8. Internal Respiration Slide 13.34a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Exchange of gases between blood and body cells  An opposite exchange to what occurs in the lungs  Carbon dioxide diffuses out of tissue to blood  Oxygen diffuses from blood into tissue

9. Internal Respiration Slide 13.34b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.11

10. External Respiration, Gas Transport, and Internal Respiration Summary Slide 13.35 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.10

11. Quick Quiz What is occurring during External Respiration? –Describe where Oxygen and Carbon Dioxide are coming from and going to What is occurring during Internal Respiration? –Describe where Oxygen and Carbon Dioxide are coming from and going to

12. Neural Regulation of Respiration Slide 13.36 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Activity of respiratory muscles is transmitted to the brain by the phrenic and intercostal nerves  Neural centers that control rate and depth are located in the medulla  The pons appears to smooth out respiratory rate  Normal respiratory rate (eupnea) is 12–15 respirations per minute  Hypernia is increased respiratory rate often due to extra oxygen needs

13. Neural Regulation of Respiration Slide 13.37 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 13.12

14. Respiratory Rate & Depth What do you think will happen to your rate and depth of respiration in each of the following situations –Increased Carbon Dioxide in the blood –Decreased Oxygen in the blood

15. Factors Influencing Respiratory Rate and Depth Slide 13.38 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Physical factors  Increased body temperature  Exercise  Talking  Coughing  Volition (conscious control)  Emotional factors

16. Factors Influencing Respiratory Rate and Depth Slide 13.39a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Chemical factors  Carbon dioxide levels  Level of carbon dioxide in the blood is the main regulatory chemical for respiration  Increased carbon dioxide increases respiration  Changes in carbon dioxide act directly on the medulla oblongata

17. Factors Influencing Respiratory Rate and Depth Slide 13.39b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Chemical factors (continued)  Oxygen levels  Changes in oxygen concentration in the blood are detected by chemoreceptors in the aorta and carotid artery  Information is sent to the medulla oblongata

18. Quick Quiz What is the most important chemical influencing respiratory rate and depth?

19. Aging Effects Slide 13.48 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Elasticity of lungs decreases  Vital capacity decreases  Blood oxygen levels decrease  Stimulating effects of carbon dioxide decreases  More risks of respiratory tract infection

20. Respiratory Disorders Worksheet Lung Cancer Article & Crossword