1. Presentation of the ClearPEM-Sonic mammography scanner ClearPEM-Sonic

2. 2 Breast cancer:  The most frequent cancer in women  One in nine women has breast cancer in her life X-ray mammography  Standard in breast cancer diagnosis  Based in structural tissue changes  High rate of false-positive  Less reliable in dense breasts  Less reliable in dense breasts  false negatives Breast cancer

3. 3 PET mammography X-ray mammography PET mammography PET and breast cancer PET/FDG has good sensitivity in breast cancer diagnosis Radioactive tracer FDG : glucose associated to positron emitter F-18 Glucose has strong affinity to cancer cells PEM Scanner Positron Emission MammographyPositron Emission Mammography PET equipment dedicated to breast and axila examsPET equipment dedicated to breast and axila exams Good spatial resolution ( ~ mm)Good spatial resolution ( ~ mm) Good sensitivityGood sensitivity

4. 4  New technology based in fast crystals (LSO) and avalanche photodiodes (APD) associated to low-noise integrated electronics  The new electronics has the highest integration density available worldwide: compact detectors with DoI capability  Scanner with excellent spatial resolution (1.3 mm)  Integration with ultra-sound probe with elastography from company Supersonic Imagine. ClearPEM-Sonic technology

5. 5 ClearPEM scanner

6. 6 Detector and Front End Electronics LYSO:Ce 2x2x20 mm 3 4x8 matrix (BaSO4 walls) S8550 16 Supermodules 32 Frond End Electronic Boards Hamamatsu Supermodules Integration Detector modules

7. 7 1. Water Cooling Plates 4. On-Detector Cabling 2. Supermodules 5. Service Board (LV distribution; HV regulation; Control & Monitoring) 3. Patch Panel 6. HV Matrix (HV distribution) 1 4 5 6 1 2 3 4 Detector Heads Integration

8. 8 Service Rack Workstation  DSS – Detector Safety System  DAE – Data Acquisition Electronics  HV Power Supply (500V)  LV Power Supply (3V2, 5V)  Service Manager  Acquisition Manager / Data Storage  Transformer Data Acquisition and Services

9. 9 Mechanical Integration and Assembling

10. 10 ClearPEM scanner

11. 11 Spatial resolution Resolution transaxial: 1.3 mm DoI capability allows sharp imaging With DoI 5 mm 1 mm Without DoI 3.0 mm 2.5 mm 2.0 mm 1.5 mm 1.2 mm

12. 12 Animal imaging tumor bladder 3D OSEM 6 it. – 4 sub. 2D OSEM 3 it. – 4 sub. FDG scan F-18 scan After injection 1h after Bone scan

13. 13 First breast images Na-22 source superimposed on breast data

14. PET mammography consortium Funded by 14 R&D consortium of research institutes collaborating with PETsys