1. Progress in the RNOH-IOMS Joint Academic Strategy David Marsh Professor of Clinical Orthopaedics, Institute of Orthopaedics and Musculoskeletal Science University College London Acting R&D Director, Royal National Orthopaedic Hospital Stanmore, UK Trust Board July 2008 Trust Board July 2008

2. Academic Health Science Centre Joint Academic Plan: –integration of UG and PG education –R&D management into IOMS –Research strategy EXCELLENCE, INTEGRATION EDUCATIONRESEARCH CLINICAL

3. Research Strategy Focused on musculoskeletal system but full spectrum Five themes, building on track record and patient needs  Innovative implant design  Cell therapy and tissue engineering  Disability and improvement of quality of life  Building the musculoskeletal evidence base  Sarcoma medicine Basic science Translational Experimental Clinical trials Health services research

4. Academic Research Board Research Committee Education Committee Trust Board PPI group UCL and Partners Health Sciences Research Deanery Institute of Orthopaedics and Musculoskeletal Science UCL Dean and Research Vice- Provost

5. 0506070809101112 NHS R&D UCL NIHR Applied Research Programme £2m Pfizer fracture accelerating drug 500k TSB grant 500k MRC stem cells in nonunion 300k Expenditure Grant target overheads, contributions to salary, SCRF profit

6. Update Research Committee Clinical research facility Cell therapy GMP facility Funding

7. Research Committee Meeting fortnightly Agenda evolving –Research governance: trial masterfiles, investigator files, GCP –Clinical research, pipeline –Links with LCRN, Deanery etc First meeting of Academic Board planned for September Rob HurdExec Team Nerina BeeAcademic Business Development Joseph FatukasiR&D Manager Simon GrangeClinical SL, Assistant R&D Director Richard KeenResearch-active consultant Sue MarchettoLead research nurse David MarshClinical Professor, R&D Director

8. Cell-based therapy Previous clinical trials in ACI Preclinical work on bone, collagen Regenerative Medical Systems – UK –Lease signed for Centennial Park –Permanent staff coming in Sep –On stream Q1 - 2009 –Scientific Board Translational teams: –Bone,Tendon,Cartilage

9. MRC Translational Research Call £241m extra, most on translational research –Bottlenecks Pan-UCL bid going in –MRC Centre for Cell and Gene Therapy Stanmore hopefully to contribute cell therapy in the musculoskeletal system

10. Funding Extra £196k from NIHR Grants secured –MRC cells in impaction grafting –Vibration therapy in distraction osteogenesis –Instrumented IM nail –ITAP –~15 trials in the pipeline Grants in preparation Full economic costing