1. Aspirin A medical miracle Source: http://jakeandkims.blogspot.com/2010/07/medicine-highlight-aspirin.htmlhttp://jakeandkims.blogspot.com/2010/07/medicine-highlight-aspirin.html

2. Index Reason for this topic History Chemistry of aspirin Uses Contra-indications Side effects Conclusion Questions, discussion

3. Why talk about aspirin? Most people come across aspirin You can teach an old dog new tricks!

4. History Hippocrates, father of medicine Left records of relieving pain

5. History Hippocrates, father of medicine 460 – 377 BC

6. History Hippocrates of Kos

7. History Hippocrates of Kos

8. 1829 Hippo- crates used the willow tree

9. 1829 It’s in willow tree bark

10. 1829 It’s salicin does the job! But… side effects

11. 1853 France: Charles Frédéric Gerhardt neutralizes salicin with: – sodium – acetyl chloride

12. 1853 France: Charles Frédéric Gerhardt neutralizes salicin with: – sodium – acetyl chloride

13. 1900 Germany: Felix Hoffmann Bayer patents the drug Its name: aspirin

14. 1900 Germany: Felix Hoffmann Bayer patents the drug Its name: aspirin

15. 1900 Germany: Felix Hoffmann Bayer patents the drug Its name: aspirin

16. Chemistry salicylic acid

17. Chemistry acetic anhedryde

18. Chemistry aspirin

19. Uses Various pains, e.g. –painful periods –headaches Fever Stroke Heart attack and heart attack prevention Arthritis Prevention of blood clots

20. 1829 Special case Stopping a heart attack Advice: –Have aspirins ready –Chest pains? Chew one

21. Side effects Abdominal pains, cramps Stomach irritation Heartburn Nausea/vomiting

22. When not to use On women –during pregnancy, especially after 6 months –when breastfeeding On children In case of: –Salicates allergy –Ulcers –Bleeding disorders

23. Properties Aspirin is absorbed in stomach

24. Functions Decreasing pain Decreasing fever Preventing blood clots Countering strokes and arthitis

25. More http://www.periodicvideos.com/videos/mv_aspirin.htm http://en.wikipedia.org/wiki/Aspirin

26. Any questions?