1. Azurin, Edelyn Babaran, Krystel

2. Mode of Action inhibit the fungal cytochrome P-450 3-A dependent enzyme 14-alpha demethylase inhibit the fungal cytochrome P-450 3-A dependent enzyme 14-alpha demethylase interrupt the synthesis of ergosterol depletion of ergosterol in the cell membrane accumulation of toxic intermediate sterols depletion of ergosterol in the cell membrane accumulation of toxic intermediate sterols increased membrane permeability inhibition of fungal growth http://www.doctorfungus.org/thedrugs/antif_pharm.htm

6. Antimicrobial Coverage

7. Side Effects more common side effects, mild and short- lived. Drug is generally well tolerated. – Diarrhea – Nausea & vomiting – stomach pain – abnormal taste in the mouth – Headache – Acne http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf

8. Side Effects serious side effects, rare, may need urgent medical attention: – Skin reactions/ rash – Bleeding or bruising more easily than normal – Flaking of the skin – Yellowing of the skin or eye, which may indicate hepatitis – Worsening of your infection, with symptoms such as fever, severe chills http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf

9. Side Effects very serious side effects; very rare; need urgent medical attention or hospitalization. – Symptoms of a hypersensitivity reaction swelling of the face, lips, mouth or throat  difficulty in swallowing or breathing – Allergic reactions which can cause shortness of breath or difficulties breathing – Fits or seizures – Fast or irregular heartbeat http://www.mydr.com.au/cmis/ReducedPDFs/CMR09213.pdf