1. Figure A1 – Relation between PFGE SmaI/Cfr9I clusters (80% similarity cut-off DICE/UPGMA) and emm sequence types for the 325 strains.

2. Figure A2 – Relationship between MLST sequence type and emm sequence type for the 795 strains that had unambiguous information about both ST and emm type in the S. pyogenes MLST database (http://spyogenes.mlst.net-presently with a total of 847 total strains). The horizontal and vertical lines limit the clusters with more than 4 elements. For each typing method, the five clusters with more elements have the corresponding type identified on the appropriate axis.

3. (1) (2) Figure A3 – Relations between emm types and ST for 795 isolates referenced in the online spyogenes.mslt.net database: (1) distribution of emm sequence type per MLST ST; (2) distribution of MLST ST per emm sequence type

4. (1) (2) Figure A4 – Probability matrices for the concordance between emm sequence type and MLST ST assignments for 41 strains. The color scale represents the probability of the event in our data set of 41 strains (1) probability of a strain with a given emm sequence type having a ST type (2) probability of a strain with a given ST type having an emm sequence type.