1. The Indiana Physician-Scientist Initiative David S. Wilkes, MD Executive Associate Dean for Research Affairs April 19, 2010

2. Changing Research Landscape Academia:Academia:  Continued strengths in basic science  Growing emphasis on translational research Industry:Industry:  Less basic science research  Seeks more clinical validation of academic research Physician-scientist training meets these needs – but a growing shortagePhysician-scientist training meets these needs – but a growing shortage April 19, 2010Indiana CTSI Annual Meeting

3. The Indiana Physician-Scientist Initiative Established December 2009Established December 2009 Lilly Endowment grant – $60 millionLilly Endowment grant – $60 million Strengthen translational researchStrengthen translational research Recruit physician-scientistsRecruit physician-scientists Support MD/PhD training programSupport MD/PhD training program Create Indiana BiobankCreate Indiana Biobank Support Global Health InitiativeSupport Global Health Initiative Enhance Translational Acceleration program (ITRAC)Enhance Translational Acceleration program (ITRAC) Indiana CTSI Annual MeetingApril 19, 2010

4. Physician-Scientist Recruitment $37.5 million for recruitment$37.5 million for recruitment  Matched by departments Highly-competitive 5-year startup packagesHighly-competitive 5-year startup packages Seeking funded mid-level MD or MD/PhD scientistsSeeking funded mid-level MD or MD/PhD scientists Targeting, but not exclusively:Targeting, but not exclusively:  Cancer  Neurosciences  Diabetes / Cardiovascular Indiana CTSI Annual MeetingApril 19, 2010

5. Training Future Physician-Scientists $10 million endowment ensures future of IU Medical Scientist Training Program$10 million endowment ensures future of IU Medical Scientist Training Program Expanded in 2001 with Indiana Genomics Initiative (INGEN) supportExpanded in 2001 with Indiana Genomics Initiative (INGEN) support Full scholarship support for 50 studentsFull scholarship support for 50 students Partnership with Purdue Biomedical EngineeringPartnership with Purdue Biomedical Engineering Achieved NIH-designated MSTP statusAchieved NIH-designated MSTP status Indiana CTSI Annual MeetingApril 19, 2010

6. Indiana Biobank $6M investment in world class biobank$6M investment in world class biobank >5,000 sq ft>5,000 sq ft Goal: Collect samples on all eligible patients who enter our health systemGoal: Collect samples on all eligible patients who enter our health system $2M investment for database management & analysis$2M investment for database management & analysis Indiana CTSI Annual MeetingApril 19, 2010

7. Global Health Initiative $2M investment in international research$2M investment in international research IU Center for Global HealthIU Center for Global Health Build on world-class Kenya programBuild on world-class Kenya program Build on ICTSI members’ expertise in infectious diseaseBuild on ICTSI members’ expertise in infectious disease Initiatives in China, Mexico, Honduras and moreInitiatives in China, Mexico, Honduras and more Indiana CTSI Annual MeetingApril 19, 2010

8. ITRAC $2M investment in IU Simon Cancer Center Translational Research Acceleration Collaborative$2M investment in IU Simon Cancer Center Translational Research Acceleration Collaborative Program management tools to “map” research course from lab to clinicProgram management tools to “map” research course from lab to clinic Promotes collaboration, reduces cost, speeds progressPromotes collaboration, reduces cost, speeds progress Expand beyond IUSCC to all scientistsExpand beyond IUSCC to all scientists Indiana CTSI Annual MeetingApril 19, 2010

9. IUSM rank in NIH funding (among 128 schools of medicine) 1 * * IUSM estimate – NIH no longer calculates rankings * (IUSM 17 th among public schools of medicine*) * Indiana CTSI Annual MeetingApril 19, 2010

10. Schools of Medicine Ranked by NIH Awards (Publicly Supported) RankOrganization Name Dollars AwardedAwardsPIs Market Share Dollars Awarded per PI Awards per PI NIH ARRA Funding Awarded FFY09* % of FFY09 ARRA Funding 1UNIVERSITY OF CALIFORNIA SAN FRANCISCO417,729,5429536363.68%656,8071.5062,548,7691.46% 2UNIVERSITY OF MICHIGAN AT ANN ARBOR319,054,4177745052.81%631,7911.5398,996,3782.31% 3UNIVERSITY OF CALIFORNIA LOS ANGELES308,538,4017124652.72%663,5231.5360,597,5911.41% 4UNIVERSITY OF CALIFORNIA SAN DIEGO287,149,5455973572.53%804,3401.6743,568,1501.02% 5UNIVERSITY OF WASHINGTON282,275,9456984802.49%588,0751.4599,401,3692.32% 6 UNIVERSITY OF NORTH CAROLINA CHAPEL HILL218,095,9975073171.92%688,0001.6065,198,5411.52% 7UNIVERSITY OF TEXAS SW MED CTR/DALLAS166,602,6084763151.47%528,8971.5125,974,9480.61% 8UNIVERSITY OF ALABAMA AT BIRMINGHAM156,389,0713862571.38%608,5181.5048,336,4511.13% 9UNIVERSITY OF COLORADO DENVER154,713,6994112871.36%539,0721.4332,403,1740.76% 10UNIVERSITY OF MINNESOTA TWIN CITIES 145,726,343 3872721.28%535,7591.4241,186,6480.96% 11UNIVERSITY OF VIRGINIA CHARLOTTESVILLE139,408,7443572391.23%583,3001.4931,088,1460.73% 12UNIVERSITY OF MARYLAND BALTIMORE135,600,2493472311.20%587,0141.5028,935,9960.68% 13UNIVERSITY OF IOWA133,424,3853192221.18%601,0111.4432,310,1290.75% 14UNIVERSITY OF WISCONSIN MADISON130,658,2383402321.15%563,1821.4738,771,3010.90% 15 UNIV OF MASSACHUSETTS MED SCH WORCESTER126,878,8263332111.12%601,3211.5821,754,7490.51% 16 NEW YORK UNIVERSITY SCHOOL OF MEDICINE126,417,7363222211.11%572,0261.4636,016,7180.84% 17 INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS 105,894,341 2982170.93%487,9921.3727,587,6480.64% ARRA awards are in addition to amounts listed at left Indiana CTSI Annual MeetingApril 19, 2010

11. Top-ranked Schools: More Funded PIs (Publicly Supported Schools of Medicine) Indiana CTSI Annual MeetingApril 19, 2010