1. Quaestio: What structures transport substances throughout the human body?
Nunc Agenda:
What are 3 parts of a circulatory system?
What are they called in the human body?

2. Function of the Circulatory System
To transport oxygen, nutrients, and other dissolved substances throughout the body
Remove wastes from cells
Maintain body temperature by distributing heat

3. Vertebrate circulatory system overview
Heart  pumps blood
Atrium – collects blood from veins
Ventricle – pumps blood out to the body
Blood Vessels
Arteries – carry blood away from the heart
Capillaries – tiny vessels where exchange of materials between blood and body cells occurs
Veins – carry blood toward the heart

4. Other vertebrate hearts
Fish – 2 chamber heart
1 atrium, 1 ventricle
Amphibians – 3 chamber heart
2 atria, 1 ventricle
Birds / mammals – 4 chamber
2 atria , 2 ventricles
Prevents oxygenated and deoxygenated blood from mixing, allows for more efficiency and ability to be warm-blooded

5. The Developing Heart of a Zebrafish Embryo

7. Note: In Crocodilians, heart is actually completely separated
Note: In Crocodilians, heart is actually completely separated. They can prevent blood from flowing through the pulmonary circuit while underwater by using a muscular valve.

9. Overview of Vertebrate Circulatory Systems

11. Interesting… Average adult body contains about 5 L of blood
On average , your blood circulates from your heart, throughout your body and back about every 60 seconds.
Everyday your heart beats about 100,000 times
First heartbeat in human embryo occurs about 4-5 weeks after conception
The leading cause of death in the US is heart disease

12. The heart is a muscular double-pump
Pulmonary circulation – right side of the heart pumps deoxygenated blood to the lungs
Heart  lungs
Pulmo = “lung” (latin)
-ary = “belonging to or connected with”
Systemic circulation – left side of the heart pumps oxygen rich blood to the rest of the body
Heart  brain and body

14. Blue=Deoxygenated blood.
Red = oxygenated blood

15. Lungs replenish the blood with oxygen.
How it works: RBCs pick up O2 through diffusion across the capillary membrane.

16. Pericardium – a tough membrane that covers the heart and protects it

17. The Heart The heart consists of four chambers:
1. Left Atrium
2. Left Ventricle
3. Right Atrium
4. Right Ventricle
Atria: Upper, thin-walled chambers.
Ventricles: Lower, thick-walled chambers.
Septum: A wall that separates the left and right sides of the heart.
Valves: flaps of tissue that prevent blood from flowing backwards

22. The heart Composed almost entirely of cardiac muscle
Cells are connected together in an electrical network that stimulates contraction
When one cell is stimulated, all of the fibers contract at the same time
Can work continuously without getting tired

23. Cardiac Muscle Cells

24. Human Heart Beat 2 contractions Atria contract “lub”
Begins at the SA node (sinoatrial) a.k.a. “the pacemaker”
Electrical impulse spreads causing both atria to contract
Ventricles contract “dub”
Impulse is picked up by the AV node (atrioventricular)
Split-second delay then both ventricles contract, pumping blood out of the heart
(allows both atria to contract and ventricle to fill with blood)

26. Circulation Pathways (1)
Steps:
1. Deoxygenated blood enters the right atrium of the heart from the body tissues.
This blood reaches the heart through the superior and inferior vena cava veins.
2. Deoxygenated blood is pumped from the right atrium to the right ventricle through a valve.
3. Deoxygenated blood is pumped out of the heart to the lungs by the right ventricle.
This blood is pumped out through the pulmonary artery.
4. The lungs replenish the blood with oxygen. It is now oxygenated blood.

27. Circulation Pathways (2)
Steps:
5. Oxygenated blood enters the left atrium of the heart from the lungs.
This blood reaches the heart through the pulmonary veins.
6. Oxygenated blood is pumped from the left atrium to the left ventricle through a valve.
7. Oxygenated blood is pumped out of the heart to the body tissues by the left ventricle.
This blood is pumped out through the aorta.
8. The body tissues use the oxygen carried by the red blood cells. The blood then becomes deoxygenated and must be returned to the heart where the cycle repeats.

28. Simplified Sequence Blood flows from
Right Atrium  Right Ventricle  Lungs  Left Atrium Left Ventricle Rest of Body  Right Atrium again.
Pulmonary Circuit:
Right Ventricle  Lungs  Left Atrium
Systemic Circuit:
Left Ventricle  Body  Right Atrium

31. Questions
The left ventricle is the largest chamber of the heart. How is its size related to its function?
If the valves in the right ventricle do not close properly, where in the body might circulation be affected the most?
Why is it important to have two separate pathways for circulation?
Describe some of the adaptations of the mammalian heart that allow it to be efficient and coordinated.