1. IKMG – International Kidney and Monoclonal Gammopathy Research Group 2nd International Meeting La Rochelle, France, September 3-4, 2015 http://internationalkidneymonoclonalgammopathy.org Dear Friends and Colleagues, We would like to invite you to attend the second international IKMG meeting in La Rochelle which is taking place in September 2015. The goal of the IKMG is to promote research into, and understanding of, kidney diseases resulting from monoclonal gammopathies and we are very excited about the program our organizing committee has put together. We plan to include state of the art lectures on the pathology, diagnostics and treatment of monoclonal gammopathy-related kidney diseases presented by experts from around the world. A poster and plenary session will cover the latest advances in this evolving field. This meeting will hopefully stimulate exchanges between clinicians and researchers, and open up new perspectives for diagnostic and therapeutic approaches to the treatment of these rare disorders, through a better understanding of their pathophysiological mechanisms. Call for abstracts will be announced in May. La Rochelle is a very pleasant city located on the west coast of France. The meeting will be held at the Espace Encan, close to the old port in the historical city center, with a wide choice of hotels within walking distance. The social program will be a unique opportunity to discover the best local food. We look forward to meeting you in La Rochelle, Guy Touchard, Congress President, Frank Bridoux, Congress Vice-President, Nelson Leung, IKMG President * ERA-EDTA’s endorsement is for the promotion of education in general, therefore the specific content of the event/course is the responsibility of the organizer Online Registration and Hotel Reservation: http://reservation.larochelle-evenements.fr/event/registration?eventid=73 Contact: Tiffany Barbier, La Rochelle Evenements, Quai Louis Prunier – BP 3106 17033 La Rochelle cedex 01, France Tel : (33) 5 46 45 91 43. www.larochelle-evenements.fr e-mail address: resa@larochelle-evenements.frresa@larochelle-evenements.fr Registration fees (including lunch and dinner on Thursday September 3rd): Seniors: 325 Euros MD or PhD age less than 35 years: 175 Euros Trainees, PhD students: 75 Euros The number of participants will be limited to 250, registration will close on Monday August 31, 2015 *

2. FINAL PROGRAM Thursday, Sept. 3. 8:00 a.m. – 10:00 a.m. Monoclonal gammopathy of renal significance – MGRS Moderators: Guy Touchard and Robert Kyle - Introduction: Guy Touchard and Nelson Leung - The history of monoclonal gammopathies: Robert A. Kyle (Mayo Clinic, Rochester, MN, USA) -Classification of renal disorders in monoclonal gammopathies: Guy Touchard (University of Poitiers, France) -MGRS: an evolving concept: Nelson Leung (Mayo Clinic, Rochester, MN, USA) - The kidney biopsy in MGRS: recent advances in pathology: Samih Nasr (Mayo Clinic, Rochester, MN, USA) - Coffee break 10:15 a.m. – 12:30 a.m. Proximal Tubule in Monoclonal Gammopathy: From the microscope to the Lab Moderators: Pierre Ronco and Maria Picken - Light chain (LC) tubulopathy with crystals: Vivette D’Agati (Columbia University, New-York, NY, USA) - LC proximal tubulopathy without crystals: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA) - LC-induced interstitial nephritis: Maria M. Picken (Loyola University Medical Center, Chicago, IL, USA) - Inflammatory pathways involved in proximal tubular injury: Veichi Batuman (Tulane University, New Orleans, LA, USA) - Panel discussion 2:00 p.m. – 3:00 p.m. Update on monoclonal protein detection/measurement Moderators: Helen Lachmann and Arnaud Jaccard - New free light chain assays: Ashu Wechalekar (National Amyloidosis Centre, London, UK) - Mass spectrometry: David Murray (Mayo Clinic, Rochester, MN, USA) 3:00 p.m. – 4:00 p.m. New Renal response and emerging therapies in AL amyloidosis Moderators: Joan Blade and Julian Gillmore - Assessing renal response in AL amyloidosis: Giampaolo Merlini (University of Pavia, Italy) - Anti-SAP therapy: Philip Hawkins (National Amyloidosis Centre, London, UK) - Coffee break 4:30 p.m. – 6:00 p.m. Update on the management of myeloma cast nephropathy Moderators: Jean Paul Fermand and Nelson Leung - Chemotherapeutic options: Efstathios Kastritis (University of Athens, Athens, Greece) - Free light chain removal: Colin Hutchison (Hawke's Bay DHB, New Zealand) - Response measurement: Heinz Ludwig (Wilhelmine Hospital, Vienna, Austria) - Group discussion 6:00 p.m. Poster viewing and wine reception, dinner to follow Financial Sponsors:

3. FINAL PROGRAM Friday, Sept. 34 8:30 a.m. – 10:30 a.m. Update in pathophysiology: animal models Moderators: Michel Cogne and Pierre Aucouturier - Cast nephropathy: Paul Sanders (University of Birmingham Alabama, Birmingham, AL, USA) - LC Fanconi syndrome: mouse and cellular studies: Olivier Devuyst (University of Zurich, Switzerland) - AL amyloidosis: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA) - Randall-type MIDD: Christophe Sirac (University of Limoges, France) - Coffee break 10:45 a.m. – 12:00 a.m. C3 glomerulopathy and monoclonal gammopathy Moderators: Vivette D’Agati and Samih Nasr - C3 GP and monoclonal gammopathy: the disease spectrum: Frank Bridoux (University of Poitiers, France) - The complement system in C3GP and monoclonal gammopathy: Véronique Frémeaux-Bacchi (HEGP, Paris, France) 12:00 – 12:45: Extra-renal manifestations of monoclonal gammopathy: Jean Paul Fermand (Saint Louis University Hospital, Paris, France) 2:00 p.m. – 4:00 p.m. Oral communications Moderators: Chris Venner and Giampaolo Merlini 4:00 p.m. Closing remarks 4:30 p.m. – 5:30 p.m. IKMG board meeting 5:30 p.m. – 7:00 p.m. Public patient conference with the participation of the Fédération nationale d’Aide aux Insuffisants rénaux, Association Française contre l’Amylose, Association Française des Malades du Myélome Multiple Academic sponsors INTERGROUPE FRANCOPHONE DU MYÉLOME FONDATION FRANCAISE POUR LA RECHERCHE CONTRE LE MYELOME ET LES GAMMAPATHIES