1. J Heart Lung Transplant 2009;28: 989-1049 THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: TWENTY-SIXTH ANNUAL REPORT ISHLT 2009

2. J Heart Lung Transplant 2009;28: 989-1049 MAJOR CONTRIBUTORS TO THE ISHLT TRANSPLANT REGISTRY OrganizationCountriesHeartLung Australia and New Zealand Cardiothoracic Organ Transplant Registry (ANZCOTR) Australiaxx Eurotransplant (ET) Austria, Belgium, Croatia, Germany, Netherlands, Slovenia xx Organización Nacional de Trasplantes (ONT) Spainx Scandiatransplant Denmark, Finland, Norway, Sweden xx United Kingdom Transplant Services Authority (UKTSSA) United Kingdom, Ireland xx United Network for Organ Sharing (UNOS) United Statesxx In addition, 83 individual centers from North America, Central/South America, Europe, Asia, Africa and the Middle East have reported at least one transplant since 1995.

3. J Heart Lung Transplant 2009;28: 989-1049 ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ISHLT 2009

4. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY STEERING COMMITTEE Marshall Hertz – Medical Director Jason Christie – Associate Dir. for Lung Transplantation David O. Taylor – Associate Dir. for Heart Transplantation Josef Stehlik – Associate Dir. for Heart Transplantation Richard Kirk – Associate Dir. for Pediatric Heart Transplantation Paul Aurora – Associate Dir. for Pediatric Lung Transplantation Axel Rahmel – Associate Dir. for OEO and Transplant Center Relations Fabienne Dobbels - Associate Dir. for Outcomes Analysis Amanda Rowe – ISHLT Executive Director Leah Edwards – Associate Dir. for Data Analysis ISHLT 2009

5. J Heart Lung Transplant 2009;28: 989-1049 General Registry Statistics ISHLT 2009

6. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Transplants Reported ORGAN Transplants Reported from 7/1/2007 through 6/30/2008 Total Transplants Reported through 6/30/2008 Heart3,20884,740 Heart-Lung603,466 Lung2,56029,732 ISHLT 2009

7. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Transplants Organ Centers Ever Reporting Data Centers Reporting Transplants in 1997 Centers Reporting Transplants between 1/2007 and 6/2008 Heart363239214 Heart-Lung1485344 Lung214118126 ISHLT 2009

8. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2009

9. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2009

10. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2009

11. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2009

12. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2009

13. J Heart Lung Transplant 2009;28: 989-1049 REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2009

14. J Heart Lung Transplant 2009;28: 989-1049 APPENDIX ISHLT 2009

15. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT ARGENTINA Fundacion Favaloro x Hospital Italiano x AUSTRALIA 1 St. Vincent x Royal Children x The Prince Charles Hospital x The Alfred Hospital x Royal Perth Hospital x AUSTRIA 2 Allgemeines Krankenhaus Wien x Universitätsklinik Innsbruck x Landeskrankenhaus Graz x (Contd) ISHLT 2009

16. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT BELGIUM 2 Hôpital Erasme Bruxelles x Universitair Ziekenhuis Antwerpen x Onze Lieve Vrouw Ziekenhuis Aalst x Universitair Ziekenhuis Gent x Centre Hospitalier Universitaire Liège x Cliniques Universitaires, Université Catholique de Louvain x UZ Gasthuisberg Leuven x BRAZIL Heart Institute-Univ. Sao Paulo Hospital das Clinicas x Hospital de Messejana x CANADA Royal Victoria Hospital x (Contd) ISHLT 2009

17. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT CANADA (contd) The Toronto General Hospital x Hospital Notre-Dame x Quebec Heart Institute - Laval Hospital x Ottawa Heart Institute x Health Sciences Centre x University of Alberta Hospitals/Walter C. Mackenzie Health Sciences x The Hospital For Sick Children x CHILE Hospital Gustavo Fricke x COLOMBIA Cliniica Cardiovascular x (Contd) ISHLT 2009

18. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT CROATIA 2 University Clinical Hospital Zagreb x University Hospital Dubrava x DENMARK 3 Skejby University Hospital x Rigshospitalet, National University Hospital x FINLAND 3 Helsinki University Central Hospital x Children's Hospital, Univ. of Helsinki x GERMANY 2 Universität des Saarlandes Homburg/Saar x Herzzentrum Dresden GmbH x Deutsches Herzzentrum Berlin x (Contd) ISHLT 2009

19. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT GERMANY 2 (contd) Universitätsklinik Köln x Universität Leipzig - Herzzentrum x Kerckhoff Klinik, Bad Nauheim x Klinikum der Universität Regensburg x Herzzentrum Nordrhein-Westfalen Bad Oeynhausen x Universitätsklinikum Essen x Johannes Gutenberg Universität Mainz x Universitätsklinikum Münster x Ruprecht-Karls-Universität Heidelberg x Medizinische Hochschule Hannover x Universitätsklinikum Göttingen x Universitätsklinikum Aachen x (Contd) ISHLT 2009

20. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT GERMANY 2 (contd) Klinikum Fulda x Klinikum der Justus-Liebig-Universität Giessen x Universitätsklinikum Schleswig-Holstein Kiel x Johann Wolfgang Goethe Universität Frankfurt/Main x Friedrich Schiller Universität Jena x Friedrich Alexander Universität Erlangen x Universitätsklinikum Würzburg x Ludwig Maximilians Universität München x Deutsches Herzzentrum München x Universitätsklinikum Hamburg x Klinikum der Albert-Ludwigs-Universität Freiburg im Breisgau x (Contd) ISHLT 2009

21. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT GREECE Onassis Cardiac Surgery Center x HUNGARY Hungarian Institute of Cardiology x IRELAND 4 Mater Hospital x ISRAEL Rabin Medical Center (Belinson Campus) x ITALY Niguarda CA Granda Hospital x Policlinico S. Orsola - Universita degli Studi x (Contd) ISHLT 2009

22. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT JAPAN Tohoku University Hospital x Saitama Medical School Hospital x KOREA Yongdong Severance Hospital x NETHERLANDS 2 Universitair Medisch Centrum Utrecht x Erasmus Medisch Centrum Rotterdam x Universitair Medisch Centrum Groningen x NEW ZEALAND Green Lane Hospital x Auckland City Hospital x (Contd) ISHLT 2009

23. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT NORWAY 3 Rikshospitalet - National Hospital of Norway x SLOVENIA 2 University Medical Center Ljubljana x SOUTH AFRICA Milpark Hospital x SPAIN Complejo Hospitalario Universitario Juan Canalejo 5 x Hospital Universitario Marques De Valdecilla 5 x Hospital Universitario Reina Sofia 5 x Hospital Universitario Puerta De Hierro 5 x Hospital Universitario La Fe 5 x Hospital Clinic Barcelona x (Contd) ISHLT 2009

24. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT SPAIN (contd) Hospital Universitario Vall DHebron 5 x Hospital Central DE Asturias x SWEDEN 3 Karolinska University Hospital, Solna x Sahlgrenska University Hospital x University Hospital of Lund x TAIWAN Cheng-Hsin General Hospital x (Contd) ISHLT 2009

25. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED KINGDOM 4 Great Ormand Street Hospital for Children x University of Glasgow/Glasgow Royal Infirmary x The Freeman Hospital x Harefield Hospital x Wythenshawe Hospital x Queen Elizabeth Hospital x Papworth Hospital x (Contd) ISHLT 2009

26. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 Univ. of Alabama Hospital, Birmingham, AL x Baptist Medical Center, Little Rock, AR x Arkansas Childrens Hospital, Little Rock, AR x Mayo Clinic Hospital, Phoenix, AZ x St Josephs Hosp and Med Ctr, Phoenix, AZ x University Medical Ctr, Univ. of AZ, Tucson, AZ x Childrens Hospital Los Angeles, Los Angeles, CA x Cedars-Sinai Med Center, Los Angeles, CA x Loma Linda Univ. Med Ctr, Loma Linda, CA x California Pacific Med Ctr, San Francisco, CA x UCSD Medical Center, San Diego, CA x Univ. of CA San Francisco Med Ctr, San Francisco, CA x (Contd) ISHLT 2009

27. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Sutter Memorial Hospital, Sacramento, CA x Sharp Memorial Hospital, San Diego, CA x Stanford Univ. Med Ctr, Stanford, CA x UCLA Medical Center, Los Angeles, CA x USC University Hospital, Los Angeles, CA x The Children's Hospital, Aurora, CO x University of Colorado Hospital/HSC, Aurora, CO x Hartford Hospital, Hartford, CT x Yale New Haven Hosp, New Haven, CT x Washington Hospital Center, Washington, DC x Alfred I duPont Hospital for Children, Wilmington, DE x All Childrens Hospital, St. Petersburg, FL x (Contd) ISHLT 2009

28. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007-6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Jackson Memorial Hosp, Miami, FL x Mayo Clinic Florida, Jacksonville, FL x Tampa General Hospital, Tampa, FL x Shands Hosp at Univ. of FL, Gainesville, FL x Children's Healthcare of Atlanta, Atlanta, GA x Emory Univ. Hospital, Atlanta, GA x Med College of Georgia Hosp, Augusta, GA x St. Joseph's Hosp of Atlanta, Atlanta, GA x Hawaii Medical Center – East, Honolulu, HI x Univ. of Iowa Hosp and Clinics, Iowa City, IA x Advocate Christ Medical Center, Oak Lawn, IL x Children's Memorial Hospital, Chicago, IL x (Contd) ISHLT 2009

29. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007-6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Loyola Univ. Med Center, Maywood, IL x Northwestern Memorial Hospital, Chicago, IL x Rush University Med Ctr, Chicago, IL x Univ. of Chicago Med Ctr, Chicago, IL x Clarian Health-Methodist/IU/Riley, Indianapolis, IN x Lutheran Hosp of Ft Wayne, Ft Wayne, IN x St Vincent Hosp and Health Care Ctr, Indianapolis, IN x Via Christi Reg Med Center, Wichita, KS x Jewish Hospital, Louisville, KY x Kosair Childrens Hosp, Louisville, KY x Univ. of Kentucky Med Ctr, Lexington, KY x Ochsner Foundation Hospital, New Orleans, LA x (Contd) ISHLT 2009

30. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Tulane Medical Center, New Orleans, LA x Children's Hospital Boston, Boston, MA x Massachusetts General Hospital, Boston, MA x Tufts Medical Center, Boston, MA x Brigham and Womens Hosp, Boston, MA x Johns Hopkins Hospital, Baltimore, MD x Univ. of Maryland Med System, Baltimore, MD x Children's Hosp of Michigan, Detroit, MI x Henry Ford Hospital, Detroit, MI x Univ. of Michigan Med Ctr, Ann Arbor, MI x Abbott Northwestern Hospital, Minneapolis, MN x St Marys Hospital (Mayo Clinic), Rochester, MN x (Contd) ISHLT 2009

31. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Univ. of Minnesota Medical Center, Minneapolis, MN x Barnes-Jewish Hospital, St. Louis, MO x Cardinal Glennon Childrens Hosp, St. Louis, MO x St. Louis Children's Hospital, St Louis, MO x St Lukes Hosp of Kansas City, Kansas City, MO x St. Louis University Hospital, St Louis, MO x Univ. of MS Med Ctr, Jackson, MS x NC Baptist Hospital, Winston Salem, NC x Carolinas Med Ctr, Charlotte, NC x Duke University Medical Center, Durham, NC x UNC Hospitals, Chapel Hill, NC x BryanLGH Medical Center East, Lincoln, NE x (Contd) ISHLT 2009

32. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) The Nebraska Medical Center, Omaha, NE x Newark Beth Israel Med Ctr, Newark, NJ x Robert Wood Johnson University Hosp, New Brunswick, NJ x Albany Med Center Hospital, Albany, NY x The Presbyterian Hosp in NY City, New York, NY x Strong Memorial Hospital, Rochester, NY x Montefiore Medical Center, Bronx, NY x Mount Sinai Med Center, New York, NY x Westchester Medical Center, Valhalla, NY x Cleveland Clinic Foundation, Cleveland, OH x Nationwide Children's Hospital, Columbus, OH x Children's Hosp Med Ctr, Cincinnati, OH x (Contd) ISHLT 2009

33. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Ohio State Univ. Med Ctr, Columbus, OH x Univ. of Cincinnati Medical Center, Cincinnati, OH x Univ. Hosp of Cleveland, Cleveland, OH x Integris Baptist Med Ctr, Oklahoma City, OK x Saint Francis Hospital, Tulsa, OK x Providence Portland Medical Center, Portland, OR x Oregon Health and Science University, Portland, OR x Allegheny General Hosp, Pittsburgh, PA x Children's Hospital of Pittsburgh, Pittsburgh, PA x Childrens Hosp of Philadelphia, Philadelphia, PA x Penn State Milton S Hershey Med Ctr, Hershey, PA x Hahnemann University Hospital, Philadelphia, PA x (Contd) ISHLT 2009

34. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) The Lankenau Hospital, Wynnewood, PA x Univ. of Pittsburgh Med Ctr, Pittsburgh, PA x Thomas Jefferson Univ. Hosp, Philadelphia, PA x Temple Univ. Hospital, Philadelphia, PA x The Hosp of the Univ. of PA, Philadelphia, PA x Cardiovascular Ctr of PR, San Juan, PR x Medical Univ. of SC, Charleston, SC x Baptist Memorial Hosp, Memphis, TN x St. Thomas Hospital, Nashville, TN x Vanderbilt Univ. Med Ctr, Nashville, TN x University Hospital, San Antonio, TX x Children's Med Ctr of Dallas, Dallas, TX x (Contd) ISHLT 2009

35. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007-6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Seton Medical Center, Austin, TX x Medical City Dallas Hospital, Dallas, TX x St Luke's Episcopal Hospital, Houston, TX x Methodist Specialty & Transplant Hosp, San Antonio, TX x Univ. of Texas Med Branch, Galveston, TX x The Methodist Hospital, Houston, TX x Christus Santa Rosa Medical Center, San Antonio, TX x University Hospital - St. Paul, Dallas, TX x Texas Children's Hospital, Houston, TX x Baylor University Medical Center, Dallas, TX x Intermountain Medical Center, Murray, UT x Univ. of Utah Medical Center, Salt Lake City, UT x (Contd) ISHLT 2009

36. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Primary Childrens Med Ctr, Salt Lake City, UT x Inova Fairfax Hosp, Falls Church, VA x MCV Hospitals, Richmond, VA x McGuire VA Medical Center, Richmond, VA x Sentara Norfolk General Hospital, Norfolk, VA x Univ. of Virginia HSC, Charlottesville, VA x Children's Hosp & Reg Medical Center, Seattle, WA x Sacred Heart Med Ctr, Spokane, WA x Univ. of Washington Med Ctr, Seattle, WA x Childrens Hosp of Wisconsin, Milwaukee, WI x Froedtert Mem Lutheran Hosp, Milwaukee, WI x ISHLT 2009 (Contd)

37. J Heart Lung Transplant 2009;28: 989-1049 Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2007- 6/2008 and Reported to ISHLT UNITED STATES 6 (contd) Aurora St. Luke's Medical Center, Milwaukee, WI x Univ. of Wisconsin Hosp and Clinics, Madison, WI x ISHLT 1 Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCOTR) 2 Data provided via Eurotransplant (ET) 3 Data provided via Scandiatransplant 4 Data provided via United Kingdom Transplant Support Service Authority (UKTSSA) 5 Lung data provided via Organización Nacional de Trasplantes (ONT) 6 Data provided via United Network for Organ Sharing (UNOS) 2009