1. MC-180MA Multi-Frequency Body Composition Analyzer

2. -Table of Contents  MC-180MA Main Feature Advanced Technology, Improvement  Advanced Technology Multi-Frequency, Reactance, Dilution method.  Measurement Result Fat %, TBW, ECW, ICW, Visceral Fat, etc. MC-180MA Introduction

3. The Advanced Technology  MC-180MA provide accurate and reliable information by Multi-Frequency BIA  Reactance / Resistance data are output each frequency  New measurement items are added to existing models MC-180MA Main Feature

4. Improvements  New additional measurement items by Multi-Frequency BIA Intra / Extra cellular water Visceral fat, Muscle Balance etc.  High accuracy weighing (type approval class III) minimum value 50g (0-200kg), 100g (200-270kg)  High capacity weighing max 270kg  Easy to operate and by color touch panel. 320 x 240dots, 5.7inch, Color TFT Display MC-180MA Main Feature

5.  External printer connectable (option) (Only EPSON Stylus D88) speedy print onto the exclusive form  PC connectable by USB selectable communication port, USB / RS-232C MC-180MA Main Feature Convenient interface  High speed measurement less than 20 sec. (not include profile input time)  High speed start up less than 10 sec. USBRS-232C Printer port

6. Multi-Frequency(1) Low frequency current is unable to pass the cell membrane and it flows outside the cell. High frequency current is able to penetrate the cell membrane and can also flow within the cell. MC-180MA Advanced technology low-frequency current flow outside of cell transmit cell membrane high-frequency current Cell ICW ECW

7. Multi-Frequency(2) MC-180MA Advanced technology f = 0 f = Cell membrane capacitor ECW Resistance ICW Resistance

8. Reactance / Resistance(1) The primary cause of daily fluctuation is changes in impedance value, because the ECW (i.e. intercellular water, blood, lymph fluid, etc.) moves between arms, legs and trunk. The change of impedance value significantly affects the estimation of body composition. MC-180MA Advanced technology ECW: Increase by daily fluctuation ICW: No change MorningEvening

9. Reactance / Resistance(2) MC-180MA not only uses impedance values in the conventional way, but also adopts reactance values that can be acquired by breaking down impedance values under a regression formula to reduce daily fluctuation. MC-180MA Advanced technology

10. Dilution method(1) Total body water (TBW) and Extra cellular water (ECW) are measured by correlations of dilution method and BIA. A known concentration of marker is administered to the body, and the total water content of the body is calculated from the degree of dilution. MC-180MA Advanced technology Body Water Marker Marker TBW : D 2 O ECW : NaBr

11. Dilution method(2) Alcohol amount: 0.4 little Water : ? 0.4 / (? + 1 ) = 1% ? = 0.4 / 0.01 – 1 ? = 40 – 1 ? = 39 little MC-180MA Advanced technology Marker 1 little 40% (0.4little) 1% ? little ?+1 little

12. Comparison with the currents Model Name BC-418BC-420MC-180 Weight Measurement 0.1kg/200kg0.1kg/270kg0.05kg/1-200kg 0.1kg/200-270kg Number of electrodes 8polar4polar8polar Measurement Frequency 50 ｋ Hz 5, 50, 250, 500 ｋ Hz Measurement Impedance Impedance Resistance Reactance Measurement Range 150 ～ 1200Ω 75 ～ 1500Ω Input device Membrane switch Touch panel Display device 3 Rows, 5 Digits LCD 3 Rows, 5 Digits LCD 320 × 240 dots TFT color LCD Data Interface RS-232C USB, RS-232C Printer internal thermal printer external A4 printer (option)

13. Comparison of results Model Name BC-418BC-420MC-180 FAT % DXA(1)DXA(2)DXA(3) TBW, TBW % from FFMDilution method ICW, ECW Dilution method Visceral Fat rating MRI BMR breath gas analysis Muscle mass DXA Bone mass DXA Segmental read out DXA Fat % DXA Muscle mass DXA Fat % Score Average Muscle Score Average

14. Body Fat In MC-180, Body Fat % and Fat Mass are measured by correlation of DXA and BIA. MC-180MA Technical Notes MC-180 evaluates segmental Fat data. These data is used to check a figure and body balance.

15. Validation data Fat % MC-180MA Technical Notes -reference-

16. Fat Free Mass (FFM) TANITA has been measuring FFM by using the DXA always. In MC-180, TANITA achieved higher accuracy by adopting advanced technology. Multi-Frequency BIA and Reactance measurement. MC-180MA Technical Notes +

17. Validation data FFM MC-180MA Technical Notes -reference-

18. Total Body Water, Intra / Extra Water TBWECW and ICW including blood and lymph ECWconsists interstitial fluid, blood plasma, lymph etc. Edema is the state that interstitial fluid has increased. ICWthe fluid that exists in the cell ICW tends to increase to the muscular person because muscle tissue contains a lot of water. MC-180MA Technical Notes TBW (45-65%) fat, protein, mineral etc. ECW (30-50%)ICW

19. General transition of body water This is one example. It is neither a normal value nor a standard value. ICW 30% ICW 35-40% ICW 30% TBW 75% ECW40% ICW 35% Body weight TBW 65% ECW30% ICW 35% TBW 60-65% ECW20-30% TBW 55% ECW25% TBW 50% ECW20% ICW 30% TBW 50% ECW25% babynewborninfantchildadult – male-adult -female-elderly adult -reference- TBWECWICW newborn754035 infant653035 child60-6520-3035-40 male552530 female502030 Factor that influences body water In elderly, ICW decreases because the muscle mass reduce. In female, TBW and ICW are little than male, because the amount of muscle is comparatively few. Adipose tissue don't contain water, therefore, in obese person, ICW is a little. MC-180MA Technical Notes

20. Validation data TBW MC-180MA Technical Notes -reference-

21. Visceral Fat Rating In TANITA body composition analyzer, visceral fat rating is evaluated by correlations of the Visceral Adipose Tissue area in MRI and BIA. MC-180MA Technical Notes BMI 25 (Age 27 Male)(Age 61 Male) Visceral fat is accumulated when becoming aged. TANITA has been researching the method of measuring the visceral fat, and established the method to estimate it from BIA. Rating from 1 - 12 Indicates you have a healthy level of visceral fat. Continue monitoring your rating to ensure that it stays within the healthy range. Rating from 13 – Indicates you have an excess level of visceral fat. Consider making changes in your lifestyle possibly through diet.

22. Validation data Visceral Fat -reference- MC-180MA Technical Notes

23. Basal Metabolic Rate (BMR) The BMR is more determined by the Fat Free Mass (FFM) than by the body weight. MC-180MA Technical Notes In MC-180, the BMR is estimated by the correlation of Breath Gas analysis and FFM. Of course, FFM is measured by the BIA method.

24. Validation data BMR R = 0.900 MC-180MA Technical Notes -reference-

25. Muscle Mass In MC-180, the muscle mass is measured by the method using the correlation of DXA and BIA. MC-180MA Technical Notes MC-180 evaluates segmental muscle mass. These are convenient to check the effect of training and rehabilitation.

26. Validation data Muscle Mass MC-180MA Technical Notes -reference-

27. Estimated Bone Mass This feature indicates the amount of bone (bone mineral level, calcium or other minerals) in the body. Persons described below may obtain varying readings and should take the values given for reference purposes only. -Elderly persons -Women during or after menopause - People receiving hormone therapy “Estimated bone mass” is a value estimated statistically based on its correlation with the fat-free amount (tissues other than the fat). "Estimated bone mass" does not give a direct judgment on the hardness or strength of the bones or the risks of bone fractures. If you have concerns over your bones, you are recommended to consult a specialist physician. MC-180MA Technical Notes

28. Validation Data Bone Mass -reference- MC-180MA Technical Notes

29. Validation data ECW MC-180MA Technical Notes -reference- -Male--Female-