1. 10th Grade genetic Engineering

2. Gene transfer 101: the basics of cutting, copying, pasting and cloning genes
An introduction
Step-by-step

3. How does genetic engineering work?
Cut out desired DNA using
Insert DNA into plasmid
Insert plasmid (vector) into host cell

4. Genetic Engineering: Making Human insulin
E. Coli make human insulin

5. Genetic Engineering: Making Factor IX in sheep…
1997: Factor IX isolated and purified from sheep’s milk
to treat one hereditary form of haemophilia (Haemophilia B,
Christmas Disease)

6. The brave new world of genomics
GENOMICS – analysis of the structure and function of genomes…

7. You don’t need to know this for your test!

9. Learning about your genome
2 out of 3 of us will die of a genetically related disease
Many (some say all) diseases have a genetic cause
Genetic report cards can identify ‘potential risk’ of future illnesses

10. Do you want to know your genome?
Are you sure?

11. Gene therapy Find defective genes and ‘fix them’
Insert a healthy normal gene or gene product (lipid, protein)to achieve normal function
Most effective for single gene disorders: cystic fibrosis, Sickle Cell disease,

12. Pharmacogenomics
Uses information about your genetic make-up to determine the drug, and drug doses, that will work best for you
Currently used for treatment of:
HIV
Breast cancer
Colon cancer
Mental illness

13. Using our genome to understand human evolution
By sequencing and databasing genes, we can see similarities and
differences between species
The closer the genome match, the closer their evolutionary history
Human Chromosome 2 came from fusion of two great ape chromosomes
Karl Miller on human evolution
The time-tree of evolution

14. Ethics and the human genome
How companies are patenting your genetic code