1. The Cell Cycle-Mitosis and Meiosis
Interphase- G1, S, G2
Mitosis or Meiosis

2. The Cell Cycle
The sequence of growth and division of a cell

4. Interphase = G1, S, G2
Interphase is when the cell grows, and the organelles double prior to the actual splitting of the nucleus.
93% of a cell’s life is spent in interphase.
Interphase has three parts
Growth 1 (G1)
Synthesis (S)
Growth 2 (G2)

5. G1, S, G2 G1 is when organelles double. S when DNA is replicated.
Remember each new cell needs a complete set of organelles.
S when DNA is replicated.
Each cell needs a complete and identical set of DNA
G2 Proteins needed for Mitosis are produced.

6. Mitosis
The process by which the cell nucleus divides into two identical cell nuclei.
In some Human cells interphases lasts 15.3 hours, while mitosis lasts only .7 hours.
Occurs in a series of steps
Prophase
Metaphase
Anaphase
Telophase
Cytokinesis

7. Chromosomes Must duplicate and separate during Mitosis
Structures of the tightly packaged DNA
DNA is tangled up into a substance of chromatin
The chromatin is packaged on the chromosome

8. Chromosomal structure

9. Prophase
Chromosomes now called chromatids because they doubled to form short thick rods which pair up and line up in the center of the nucleus.
A centromere connects the two halves of the doubled chromatids.
Spindle fibers begin to form.
Spindle fiber – a fibrous structure from the cytoplasm which forms to the centriole.
Centrioles move to opposite sides of the cell.
The nuclear membrane breaks down.

10. Prophase

11. Metaphase
Centromeres of the chromatid pairs line up in the middle of the cell.
Metaphase plate- location where the centromeres line up in the center of the cell.
By the end of metaphase each chromatid has attached to spindle fibers.

12. Metaphase

13. Anaphase The spindle fibers pull the chromatids apart.
This separates each one from its duplicate. These move to opposite sides of the cell.
Now there are two identical sets of chromosomes.

14. Anaphase

15. Telophase
When the chromosomes reach opposite sides of the cell the spindle fibers break up.
The nuclear membrane begins to reform.
A furrow begins to develop between the two sets of chromosomes.

16. Telophase

17. Cytokinesis
The two identical cells completely divide and the cell membrane is completely formed.

18. Mitosis Movie 1

19. Mitosis movie 2

20. Meiosis Diploid (2n) - A cell with two of each kind of chromosome.
One chromosome from each parent.
If two body cells were to combine nuclei, the number of chromosomes would double.
In order for sexual reproduction to occur, each cell involved must reduce its chromosome number by half.
Haploid (n)- A cell with one of each kind of chromosome.

21. Haploid cells Haploid cells are called gametes
Gametes are either sperm or eggs
Organism diploid gamete
Human
Pea
Fruit fly 8 4
Dog

22. Homologous chromosomes
Are paired chromosomes with genes for the same trait arranged in the same order.
Ex. Eye color, hair color, height, one may code for blue, blonde, tall, its homolog may code for brown, blonde, short
Homologous chromosomes may have different alleles on them
Allele- gene form for each variation of a trait of an organism.

23. Meiosis
Meiosis is the process of cell division in which gametes are formed and the number of chromosomes is halved. So that sexual reproduction and zygote formation can occur.
Zygote- Fertilized egg which has a diploid number of chromosomes.

24. Stages of Meiosis Interphase- Prophase I Chromosomes replicate
Each chromosome consists of 2 identical sister chromatids
Prophase I
Each Pair of homologous chromosomes come together to form a tetrad.
Tetrad- 2 homologous chromosomes come together and the 4 chromatids overlap.

25. Crossing over Tetrads are so tight that non-sister chromatids
from the homologous pair actually exchange genetic material.
Crossing over- The exchange of genetic material by non-sister chromatids during late prophase I of meiosis.
Results in a new combination of alleles

26. Metaphase I Homologous chromosomes line up together in pairs.
* In mitosis homologous chromosomes line up in the middle independently of each other.

27. Anaphase I Spindle fibers attach to the centromeres of each pair.
Homologous chromosomes separate and move to opposite ends of the cell.
Centromeres DO NOT split like they do in mitosis
Now each cell will get one chromosome from each homologous pair.

28. Telophase I Spindle fibers break down Chromosomes uncoil
Cytoplasm divides
Another cell division is needed because the number of chromosomes has not been reduced
After telophase I there maybe a short interphase, but not always. It is important to note that if a cell does have a second interphase, there is No replication of chromosomes.

29. Meiosis I

30. Meiosis II
Is basically just like mitosis, but remember the chromosomes did not duplicate in interphase II.
Prophase II
Chromosomes begin to line up in the middle of the cell.
Spindle fibers begin to form
Metaphase II
Chromosomes line up on the metaphase plate

31. Meiosis II Anaphase II Telophase II
Centromeres split
Sister chromatids separate and move to opposite sides of the cell
Telophase II
Nuclei reform
Spindle fibers disappear
Cytoplasm divides into two.
The number of chromosomes in each daughter cell has now been reduced by half.

32. Meiosis II

33. Meiosis Movie 1