2. Lesson 9.3: Meiosis: The Life Cycle of Sex Cells Goals: Identify male and female gametes Compare chromosome numbers between somatic cells and gametes Describe the stages of meiosis Compare meiosis and mitosis

3. Meiosis Somatic cell = body cell which is DIPLOID (2n), - it has 2 copies of each chromosome (one from mom and one from dad) these are called HOMOLOGOUS CHROMOSOMES –In humans, somatic cells have 46 chromosomes (skin cells, liver cells etc.)

4. Homologous Chromosomes Homologous chromosome – one of a matching pair of chromosomes that comes from each parent Mom Dad

5. Gametes, or sex cells do not perform mitosis Human sex cells have 23 chromosomes… HOW DOES THIS HAPPEN? Gametes are involved in sexual reproduction and are HAPLOID (n) (1 set of chromosomes) –Male gamete = sperm –Female gamete = egg –In humans the sperm and egg each have 23 chromosomes

6. The Phases of Meiosis Consists of 2 separate cell divisions named Meiosis I and Meiosis II Starts with one diploid cell and ends with FOUR haploid cells called gametes (sex cells) During Meiosis I the number of chromosomes is reduced by ½ therefore meiosis I is known as reduction Meiosis II is the same as mitosis (division of the nucleus)

7. Meiosis I – PROPHASE I Preceded by Interphase (therefore chromosomes have replicated  sister chromatids) Spindle fibers appear and attach to centromeres In meiosis I HOMOLOGOUS chromosomes pair up in a process called SYNAPSIS which results in TETRADS While chromosomes are paired, they trade DNA pieces with each other  CROSSING OVER

8. Meiosis I – Metaphase I Tetrads line up randomly along the metaphase plate (tetrads meet in the middle)

9. Meiosis I – Anaphase I Homologous chromosome separate – move Away/Apart from one another towards opposite ends of the cell *Sister chromatids are still together!

10. Meiosis I – Telophase I and Cytokinesis Each end of the cell now has a haploid nucleus (nucleus only has one set of chromosomes) Nuclei and cytoplasm divide in half 2 haploid cells form Each contains 2 copies of the same set of chromosomes

11. Meiosis II Does not begin with DNA replication Prophase II: Spindle fibers attach to sister chromatids Metaphase II: spindle fibers move sister chromatids to the middle/center Anaphase II: Centromeres divide, sister chromatids separate and move apart to the poles Telophase II: Nuclear envelope reforms, cytoplasm divides Result: 4 haploid (1/2 the number of chromosomes as the original parent cell), genetically different cells

12. Lesson 3 Review Please read text pages 256-258 and answer the following questions on page 259 1. __________ 2. __________ 3. __________ 4. __________ 5. __________ 6. __________

13. Check Mitosis, Meiosis or Both MitosisMeiosisBoth No pairing of homologous chromosomes Two divisions Four daughter cells produced Associated with growth and asexual reproduction Associated with sexual reproduction One division Two daughter cells produced Involves duplication of chromosomes Chromosome # maintained Chromosome # is halved Crossing over between homologous may occur Daughter cells are identical to parent cell Daughter cells are not identical to parent cell Produces gametes Synapsis occurs in prophase

14. State the Phase State the Phase (for meiosis - indicate meiosis I or II) Mitosis –Nucleolus reappears –Sister chromatids line up at equator –Cleavage furrow forms –Cell elongates –Chromosomes move AWAY from each other –Spindle fibers stretch across the cell –Nucleolus and Nuclear membrane disappear Meiosis Tetrads form Crossing over occurs Chromatin condenses Tetrads line up at equator Sister chromatids separate and chromosomes move AWAY… Centromere divides 2 cells are formed 4 haploid cells are formed Centrioles move to opposite ends of the cell

15. Review: A comparison of mitosis and meiosis comparison animation