1. Research & clinical assessment with the IBCMT Embedded Research Program

2. IBCMT The Neuroscience Trust Research & clinical assessment IBCMT’s Embedded Research Program Medical, Scientific, Education and Research Committee (MSERC) Partnership with Brain Resource Company IntegNeuro Cognitive assessment system –Clinical assessment of patients - chargeable –Collection of research data from patients –Continuing professional development The Neuroscience Trust

3. IBCMT The Neuroscience Trust Embedded Research Program Aims and significance Creating an IBCMT clinical database Metal toxicity and neurocognitive function Data collected by international college membership using IntegNeuro Brain Resource normative database Development of an objective, evidence- based” “gold standard” for clinical use: toxicology profiles to inform the clinician

4. IBCMT The Neuroscience Trust Embedded Research Program Affiliation with Brain Resource Company (BRC) IBMCT has entered partnership with BRC to develop the IBCMT clinical database IBCMT-BRC memorandum of understanding permits Colleges to enter the alliance with BRC richard.clark@brainresource.com richard.clark@brainresource.com Each College may enter memorandum of understanding with BRC Accrual of research funds to IBCMT and affiliated Colleges based on the data contributed by clinicians to database

5. IBCMT The Neuroscience Trust Embedded Research Program The Database Toxicology groupings –Collection of data of over 5000 patients from participating IBCMT clinics –Cognitive, clinical, toxicological and diagnostic information –Collated with Brain Resource Database Normal reference group –1500 normal cases to date using IntegNeuro assessment –Aged 6– 85; males and females

6. IBCMT The Neuroscience Trust Phase 1 Data collection phase from up to 100 clinics worldwide Clinic: assessment of cognitive function & treatment efficacy Phase 2 IBCMT and College sponsored research investigations into data to determine toxicity profiles Publication of discriminant analyses on metal toxins Scientific enhancement of clinician’s diagnostic armory Clinic: cognitive assessment and neurotoxicological profiling Embedded Research Program Timeline

7. IBCMT The Neuroscience Trust Neurocognitive assessment of patients in the clinic using IntegNeuro

8. IBCMT The Neuroscience Trust Portable, computerized, automated assessment tool Easily locatable in IBCMT clinics Hardware components: IBM Kiosk Head phones and microphone Web ready status IntegNeuro software Neurocognitive assessment using IntegNeuro

9. IBCMT The Neuroscience Trust Embedded Research Program Data, tests and measurements Web questionnaire –Medical and other history IntegNeuro assessment –Neurocognitive function Clinical information –Hair analysis - toxic and nutrient elements, blood and urine levels –Toxicological diagnosis –Clinical diagnosis

10. IBCMT The Neuroscience Trust Neurocognitive assessment - staff training No psychological training required Staff involvement with patient is minimal Patient orientation Periodic patient monitoring Other staff activities Entering clinical, toxicological and diagnostic data Data uploading and printing Report Billing patient Paying the Neuroscience Trust Instructions on CD; internet and email support

11. IBCMT The Neuroscience Trust Patient allocated a unique code Patient completes web questionnaire at home or in clinic Patient completes IntegNeuro neurocognitive assessment in the clinic using the IntegNeuro Kiosk Clinical, toxicological and diagnostic data entered into Kiosk The data file is uploaded where it is automatically scored Report prepared and emailed for printing Neurocognitive assessment – patient testing procedure

12. IBCMT The Neuroscience Trust The data uploading procedure is handled by internet connection Upload procedure secure and encrypted – no patient name; only ID code used Each upload takes a few minutes Report returned by email from BRC within 72 hours Invoice emailed for payment Payment for report made via secure website at www.NeuroscienceTrust.com www.NeuroscienceTrust.com Clinic charged 85% of recommended List Price Neurocognitive assessment Data upload

13. IBCMT The Neuroscience Trust When to test and what to do if patient abnormal on IntegNeuro Initial testing provides an objective and inexpensive baseline of cognitive function If abnormal, then reassess patient after suitable interval to assess efficacy of treatment on these baseline measures as well as on toxicological measures If deemed necessary, refer for full neuropsychological assessment

14. IBCMT The Neuroscience Trust IntegNeuro Summary of procedures IntegNeuro test using allocated patient code Patient auto tested using Kiosk (50min) Report delivery by email 72 hour turnaround Web Upload to BRC Encrypted, de-linked data scored and matched to database Internet Report payment Https (secure) website www.NeuroscienceTrust.com IBCMT Clinic Report request uniquely linked to patient code Start

15. IBCMT The Neuroscience Trust Installing IntegNeuro in the clinic

16. IBCMT The Neuroscience Trust Steps to install IntegNeuro in clinic Clinic applies to The Neuroscience Trust Application forms available from richard.clark@neuroscience.com richard.clark@neuroscience.com IBM Kiosk and installed software delivered within 4-6 weeks of receipt of order Installation and operation instructions provided with equipment and software; telephone and web help as required IntegNeuro assessments can commence once equipment installed and connected to internet

17. IBCMT The Neuroscience Trust Breakeven financial model for IntegNeuro installations Kiosk sharing recommended if less than 2 tests per week Amounts have been converted to US dollars

18. IBCMT The Neuroscience Trust Established to manage the IBCMT-BRC strategic alliance involving –Embedded research program –Clinical report ordering and payments –Distribution of research funds to IBCMT and participating National Colleges Web presence: –Support facility for clinics (e.g. FAQ, test information, general procedures –Repository for research outputs –http://www.neurosciencetrust.comhttp://www.neurosciencetrust.com