1. The Federal German Funding Initiative Systems for Life - Systems Biology Structure – Coordination Jens Doutheil DECHEMA e.V. Frankfurt

2. Outline Structure Projects Coordination Project Management

3. The Structure Federal Ministry of Education and Research PTJ - The Project Management Organization Jülich International Steering Committee Project Committee 2 platform and 2 network projects with 25 partners Project management at DECHEMA e.V.

4. The International Steering Committee Prof. Dr. Dieter Oesterhelt, MPI for Biochemistry Munich (chairman) Dr. Roland Eils, DKFZ Heidelberg Prof. Dr. Joseph Heijnen, Technical University of Delft Prof. Dr. Karl Kuchler, Institute for Medical Biochemistry, University of Wien Prof. Dr. Siegfried Neumann, Merck KGaA Darmstadt Prof. Dr. Hans V. Westerhoff, Molecular Cell Physiology & Mathematical Biochemistry, BioCentrum Amsterdam

5. The Project Committee Dr. Jens Timmer, University Freiburg (chairman) Prof. Dr.-Ing. Matthias Reuss, University Stuttgart Prof. Dr.-Ing. Ernst-Dieter Gilles, MPI for Komplex Technical Systems, Magdeburg Prof. Dr. Augustinus Bader, Biomedizinisch-Biotechnologisches Zentrum, Leipzig

6. The Projects Two nationwide organized „Technology Platforms“ Platform Cell Biology (Leipzig, Aachen, etc.) Platform Modelling (MD, B, HD) Two regionally organized interdisciplinary „Collaborative Projects“ Network Regeneration (Freiburg, Heidelberg) Network Detoxification and Dedifferentiation (Stuttgart, Erlangen)

7. Structure of the National Competence Network Systems Biology

8. Cell Biology Platform Distributing Standardized Cell Material Human hepatocytes and animal equivalents Isolation protocol, culturing, starving & stimulation follow SOPs Developing Cell Lines Based on Conditional immortalized or Somatic stem cells Bioreactors with controlled microenvironment

9. Modeling / Bioinformatic Platform General aspects of mathematical modeling Generalized control theory for cellular networks Reduction of complex kinetic models Network decomposition Hybrid simulation methods Computer tools: SYCAMORE, ProMoT/DIVA Collaboration with competence network on specific projects

10. Network Regeneration Background: Liver Regeneration is a highly regulated process Goal: Understanding the pathways involved Method: Data-based mathematical models Long term goal: Support development of liver cell lines

11. Network Detoxification / Dedifferentiation Detoxification: Cytochrome P 450 isoforms Molecular dynamics Kinetic experiments Polymorphisms Dedifferentiation: Changes of metabolic pathways during dedifferentiation

12. Coordination of the Competence Network Systems Biology Secretariat for the BMBF Funding Initiative „Systems for Life – Systems Biology“ at DECHEMA e.V. in Frankfurt as Part of the Information Secretariat Biotechnology Flyer, brochures, articles, posters.... Webpages, internet representation www.systembiologie.de Public relation with journalists and media Conference visits and reports Scientific coordination of interdisciplinary research groups

13. Project Management for the Competence Network Systems Biology Partnering - workshops, kick-off workshops, annual status workshops Conference organization – conference office for the 5 th International Conference on Systems Biology, October 9 –13, 2004 in Heidelberg www.icsb2004.org Coordination of due dilligance, contracting and implementation for a Central Data Management for the funding Initiative Systems Biology Organizing the scientific reporting for PTJ, BMBF and Steering Committee