2. Materials and methods Design Open-label, randomized trial, February 2010 to May 2011, avoiding the summer period Participants recruited from a primary care centre in Sweden, serving a population with a high proportion of non-European residents Inclusion criteria age 15 years or above and vitamin D deficiency 25(OH)D3 less than 25 nmol /L Exclusion criteria light-sensitive skin ongoing treatment with vitamin D supplementation sunny holidays intake of photosensitive medicine during the study period.

4. UVB The average starting dose was 0.36 J increments were about 15% every second treatment session the average maximal (final) dose was 1.20 J. The mean cumulative dose was 9.0 J /cm2

7. Results Significantly greater increase in 25(OH)D3 levels in the NB- UVB treated group compared with the tablet-treated group after 6 weeks of treatment (P = 0.02) in the NB-UVB treated group The 25(OH)D3 levels (mean ± SD) increased from 19.2 ± 6 nmol /L to 75 ± 16.8 nmol/L vs. 23.3 ±4.4 nmol /L to 60.6 ± 16.7 nmol /L in the oral vitamin D3 treated group

8. Results No significant difference regarding PTH, calcium, albumin or HbA1c levels. A significant decrease in PTH A significant increase in calcium levels

9. Limitations lack of compliance among the group who took vitamin D3 supplements high dropout number primarily non-European immigrants

10. Conclusion exposure to a small dose of full body NB-UVB radiation three times a week is more efficient in raising vitamin D levels than prescription of a daily oral intake of 1600 IU vitamin D3

11. Race ? Skin type ?

14. Suscreen ?

17. Winter vs summer

20. NB UVB vs BB UVB ?

22. Diet ?

24. Screening ?

26. Deficiency ?

27. -Vitamin D deficiency is defined as a 25(OH)D below 20 ng/ml (50 nmol/liter) - Vitamin D insufficiency is defined as a 25(OH)D of 21–29 ng/ml

28. Daily requirement ?

31. Treatment