1. TAMMY DO TRAUMA RESEARCH ASSOCIATES PROGRAM 8.24.2012 Necrosis

2. Premature death of cells/death of body tissue Apoptosis vs. Necrosis Caused by:  Infections  Toxins  Trauma  Ischemia

3. Causes Ischemia  Thrombosis/embolism Infection/Disease  Fungal/bacterial  Diabetes Chemicals  Poisons/toxins  venom Trauma

4. Necrotic Wound from Spider Bite

5. Types of Necrosis Coagulative Liquefactive Caseous Fatty Fibrinoid Gangrenous Aseptic

6. Coagulative Necrosis Caused by ischemia Denaturation of structural proteins Enzymatic digestion of cells Architecture of tissue preserved Occurs in organs like heart, spleen, kidney Does not occur in brain

7. Liquefactive Necrosis Necrotic tissue digested by enzymes into liquid Associated with abscess formation Commonly seen in brain  ischemia Fungal or bacterial infection  Not in brain

8. Caseous Necrosis Necrotic tissue is crumbly and cheese-like Typically caused by tuberculosis  Syphilis  fungal

9. Fat Necrosis In response to trauma Lipases break down fats React with calcium: saponification Chalky white deposits Most commonly seen in pancreas and breasts  Acute pancreatitis

10. Fibrinoid Necrosis Caused by deposition of fibrin or fibrin-like materials Vasculitis

11. Gangrenous Necrosis Considerable mass of necrosis Types of gangrene  Dry  Wet  Gas Dry Necrosis  Form of coagulative  Caused by ischemia  Autoamputation  Distal parts of limbs  Dry, shrunken, black

12. Gangrenous Cont. Wet  Moist tissue and organs  Characterized by bacterial infection  Dark, swollen, foul odor Gas  Bacterial infection that produces gas within tissue  Deadly

13. Gangrenous Cont.

14. Aseptic Necrosis Avascular necrosis or osteonecrosis Necrosis of bone Lack of blood supply to bone Medications, trauma, ischemia, hypercoagulable blood, alcoholism

15. Treatment Depends on the extent of damage Restoration of blood flow Maggot Therapy Debridement Amputation

16. Sources http://onlinemedicinefacts.com/pathology/caseous- necrosis-liquefactive-necrosis-and-fibrinoid-necrosis http://onlinemedicinefacts.com/pathology/caseous- necrosis-liquefactive-necrosis-and-fibrinoid-necrosis http://www.symptomsbook.com/Facts-Therapy-Pictures- Diagnosed-Information-Diagnosis-Herceptin-Treated- necrosis-Diagnosed-Diagnosis.htm http://www.symptomsbook.com/Facts-Therapy-Pictures- Diagnosed-Information-Diagnosis-Herceptin-Treated- necrosis-Diagnosed-Diagnosis.htm http://www.medicinenet.com/aseptic_necrosis/article.htm http://www.nlm.nih.gov/medlineplus/ency/article/00226 6.htm http://www.nlm.nih.gov/medlineplus/ency/article/00226 6.htm http://www.mayoclinic.com/health/avascular- necrosis/DS00650 http://www.mayoclinic.com/health/avascular- necrosis/DS00650 http://library.med.utah.edu/WebPath/CINJHTML/CINJ0 29.html http://library.med.utah.edu/WebPath/CINJHTML/CINJ0 29.html