1. + How is the cell cycle regulated? Sections 8.8 and 8.9

2. + Factors that affect Cell Division Anchorage Dependence Cells must be in contact with solid surface in order to divide Density-Dependent Inhibition Once cells come in contact with other cells they stop dividing

3. + Factors that affect Cell Division Growth Factors Proteins secreted by certain body cells that stimulate other cells to divide

4. + Control of the Cell Cycle Built in stop signals in the cell cycle must be triggered by proteins for the cycle to progress Three major checkpoints: G1 Most important; Check size; DNA replicated G2 DNA properly replicated M Chromosomes attached to spindle fiber

5. + Cell Cycle Control

6. + How do cancer cells differ from other cells? Section 8.10

7. + Cancer Uncontrolled cell division Cells are not subject to normal cell cycle control Cells divide continuously

8. + Benign Tumor vs. Malignant Tumor Benign Tumor Not cancerous Remains at the site of origin Malignant Tumor Cancerous Abnormal mass that can/will spread to other parts of the body

9. + Metastasis The spread of cancer cells beyond their original site Cancers are named for their site or origin Carcinoma – originate in body covering (inner and outer lining) Sarcoma – originate in supportive tissues Leukemia – originate in blood forming tissues Lymphoma – originate in lymphatic system

10. + Cancer Prevention & Treatment