1. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Towards the Sixth Framework Programme Parallel Forum V 26 September 2002 Public Health Research for European Community Policies Dr. O. Quintana Trias, DG RTD European Commission

2. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Bottlenecks-European research l Fragmentation and heterogeneity l Under-resourcing l Environment less favourable to exploitation

3. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 A fundamental reassessment... l to exert a more structuring effect lto combine FP funding to a greater extent with other public & private sector funding l to link Framework Programmes more closely with national and European intergovernmental activities lEuropean added value

4. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Five major keys  Critical mass : financial / material / human resources  Mobility of researchers / engineers / technicians  Make Europe attractive to best scientists  Favourable research and innovation environment : IPR, encourage academia / industry partnerships  Increase RTD investment to up to 3% of GDP (public + private) European Research Area

5. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 6th Framework Programme: a tool â Greater concentration  Limited number of priorities of strategic importance for EU  Where EU action can add greatest value â More effective instruments â Simplified implementation  Longer term projects  Increased flexibility  Increased autonomy

6. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Integrating European Research: 7 Priority Themes Proposed budget (millions € ) 1. Genomics and biotechnology for health 2200 2. Information society technologies3600 3. Nanotechnologies, …1300 4. Aeronautics and space1075 5. Food safety and health risks 685 6. Sustainable development and global change2120 7. Citizens and governance in the knowledge society 225

7. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 ã 1.1 Genomes and biotechnology for health ã 1.2 Information society technologies ã 1.5 Food quality and safety Public Health and the 6 FP (i)

8. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 “Priority 8”: ã 1.2.1Specific activities covering a wider field of research (1.2): ã Supporting policies and anticipating scientific and technological needs (1.2.1) ã 2. Strengthening the ERA foundations Public Health and the 6 FP (ii)

9. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 1.1.1 Genomics l1.1.1.1 Advanced genomics - applications for health â Fundamental knowledge and basic tools for functional genomics in all organisms: gene expression and proteomics, structural genomics, bioinformatics, etc. â Application of knowledge and technologies in genomics and biotechnology for health: technological platforms, prevention and therapeutic tools, etc. l1.1.1.2 Combating major diseases â Application-oriented genomic approaches to medical knowledge and technologies: diabetes, cardiovascular diseases, resistance to antibiotics, brain and ageing, etc. â Cancer â Major poverty-linked infectious diseases: aids, malaria and tuberculosis

10. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 1.1.1 Genomics l1.1.1.2 Combating major diseases â1.1.1.2.1 Applications in medicine & public health Ô cardiovascular disease, diabetes, rare diseases : àintegrating clinical expertise and resources with relevant model systems and advanced tools in functional genomics ==>> breakthroughs in prevention and disease management àpool Europe’s research resources to tackle rare diseases Ô resistance to antibiotics & drugs: àexploitation of knowledge of microbial genomes and host- pathogen interactions ==>> vaccines, alternative strategies àstrategies for optimal use of antimicrobials àsupport EC network on epidemiological surveillance and control of communicable diseases

11. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 1.1.1 Genomics l1.1.1.2 Combating major diseases â1.1.1.2.1 Applications in medicine & public health : Ô studying the brain and combating diseases of the nervous system: à Understanding molecular / cellular bases of brain function, damage, plasticity and repair, learning, memory, cognition à Developing prevention and management strategies of neurological and mental disorders and diseases Ô studying human development and the ageing process: à Human development from conception to adolescence à Molecular and cellular determinants of healthy ageing, including interaction with environmental, behavioural, gender factors

12. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 1.1.1 Genomics l1.1.1.2 Combating major diseases â1.1.1.2.2 Combating cancer Ô Establishing facilities for exploitation of research: à Development of evidence-based guidelines for good clinical practice and improved public health strategies à Accelerate translation of existing research results into applications Ô Supporting clinical research / clinical trials: à Aim : validation of new and improved interventions Ô Supporting translational research: à Aim : bringing basic knowledge through to applications in clinical practice and public health

13. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 1.1.1 Genomics l1.1.1.2 Combating major diseases â1.1.1.2.3 Confronting major communicable diseases linked to poverty - a broader approach Ô Developing candidate interventions: à Vaccines, therapies and HIV microbiocides against HIV/AIDS, malaria, tuberculosis through basic molecular research, taking advantage of microbial genomics, pre-clinical testing, proof-of-principle Ô Establishing a clinical trials programme: à Aim : support Europe’s clinical trials activities targeted at interventions for use in developing countries Ô Establishing an AIDS Therapy Trials Network: à Aim : improve coherence and complementarity of clinical trials on AIDS therapies

14. European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Information lGlGeneral information on research: http://europa.eu.int/comm/research lGlGeneral information on the Sixth Framework Programme : http://europa.eu.int/comm/research/nfp.htm l lIlInformation on research programmes and projects : http://www.cordis.lu lIlInformation requests: research@cec.eu.int