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Esophagus: Normal Lower Esophageal and Squamo- columnar Junction Mucosae.

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Presentation on theme: "Esophagus: Normal Lower Esophageal and Squamo- columnar Junction Mucosae."— Presentation transcript:

1 Esophagus: Normal Lower Esophageal and Squamo- columnar Junction Mucosae

2 Esophagus: Normal Squamous Epithelium

3 Esophagus: Normal Squamo- columnar Junction

4 Esophagitis (Inflammation and Reactive Epithelial Changes of the Esophageal Mucosa) Has Many Causes

5 Reflux Esophagitis is the Culmination of Gastro-Esophageal Reflux-Induced Changes in Epithelial Cell Turnover

6 Esophagus: G-E Reflux - Changes in Epithelium and Vascular Papillae

7 Esophagus: G-E Reflux - Defenses Against Reflux-induced Injury

8 Esophagus: G-E Reflux - Symptoms and Endoscopic Findings in Reflux are NOT Predictive of Biopsy Findings

9 Esophagus: G-E Reflux - Heightened Epithelial Turnover in G-E Reflux is Shown by Increased Epithelial Tritiated Thymidine Labeling

10 Esophagus: G-E Reflux - Reflux- induced Epithelial Change Is a Consequence Of Increased Cell Turnover

11 Acute (Neutrophilic) Inflammation and Erosion In Severe Reflux Esophagitis

12 Severe Epithelial Reactive Changes with Eosinophils (EOS) in Gastroesophageal Reflux

13 Sequelae Of Prolonged G-E Reflux

14 Barrett’s Esophagus: Development And Anatomic Relationships

15 Endoscopic Landmarks In The GEJ Region: Normal Versus Barrett’s (Columnar-lined) Esophagus With Location Of Lower Esophageal Sphincter (LES)

16 Requirements For Diagnosis Of Barrett’s Esophagus

17 Barrett’s Esophagus: Gross Appearance

18 Barrett’s Esophagus Should Be Suspected And Confirmed By Biopsy When The Squamo- columnar Junction Is Displaced Or Highly Irregular

19 Barrett’s Mucosa (BM) With Submucosal Esophageal Gland (SMEG) Below Muscularis Mucosae (MM)

20 Barrett’s Mucosa: Distinctive (Specialized) Type


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