1. Visit the Exhibitors!!! They are around the corner in room Coronado A-C Represented there are Dialysis Equipment Companies Solution Companies Access Companies Book Companies

2. Welcome

3. Dear Tim, as far as I know this is the first patient treated with CAVH in the world. We performed this treatment in Vicenza in 1984 and the patient survived. After that we published the first series of 4 newborns treated with CAVH (Kidney International 1986). You made a great deal of progress since then and even more with this meeting. Best Wishes Claudio Ronco

4. Time and Transition 1984-Ronco’s KI paper 1990-CAVH becomes more common 1993-CVVH with adapted machinery 1995-automated CVVH(D) machinery 1997-ultrafiltration controllers with automated machinery 1999-Thermic controls with automated machinery

5. Time and Transition 2000-1 st International Conference on Pediatric Continuous Renal Replacement Therapy 2001-1 st FDA approved Bicarbonate Based Dialysate (Normocarb) 2001-ppCRRT Registry establishment (Stu Goldstein) 2001-Goldstein data on FO and outcome 2002-Citrate anticoagulation 2002-PCRRT 2

6. Time and Transition 2002-PEDCRRT list serve Gambro releases Prismasate 2003-DiCarlo data on early intervention in Bone Marrow Transplantation 2004-Foland data on FO and outcome 2004-Data emerging on Pharmacy Errors 2004-PCRRT 3

7. DIALYSIS MODALITY Belsha et al., Pediatr Nephrol, 1995 Patients (%)

8. Pediatric Choice of RRT # on RRT/yr Year of RRT

9. Why has this become common? Work in vascular access Dedicated staff who is interested in these children Patients continue to be sicker then historically Automated machinery has made the care easier Anticoagulation protocols have made it easier

10. CRRT: Who does it? Outside of NA > 70% of all CRRT done by Intensivists Within NA USA ~ 60% done by Nephrology but often determined by manpower Adult Nephrologists = Adult Intensivists Pediatric Nephrologists < Pediatric Intensivists Canada ~ 50% done by Nephrology

11. Who really does CRRT? Nursing staff of the Dialysis units- thank you Critical Care units- thank you Neonatal intensive Care units- thank you

12. What is the purpose of this meeting? To bring together those in the field who deal with any modality of MOSF with RRT who are willing to listen and learn, to talk and to exchange There are no experts in this field!! “If you quit learning then it is time to go home” (actually he said get the hell out before you hurt someone!) Robert Vernier MD (U of Mn, retired)

13. Thank you To those of you who helped make this meeting happen Faculty Carol Malone Program and Meeting planner PCRRT Organizing committee PCRRT Foundation, Inc

14. Who are the faculty? Desmond Bohn MB, BCh, FRCPC Pediatric Critical Care Physician @ The Hospital for Sick Children, Toronto, Ont Canada Stefano Picca MD Pediatric Nephrologist @Bambino Gesu Children’s research Hospital, Rome, Italy

15. Who are the faculty? Helen Currier BSN, RN, CNN Clinical Program Specialist Texas Children’s Hospital, Houston TX Stuart L Goldstein MD Pediatric Nephrology @ Baylor College of Medicine & Texas Children’s Hospital, Houston TX

16. Who are the faculty? Jordan Symons MD Pediatric Nephrology @ Univ of Washington, Children’s Hospital of Seattle, Seattle, Wa Patrick D Brophy MD FRCPC Pediatric Nephrologist University of Michigan, Ann Arbor MI

17. Who are the faculty? Nancy Hawkins McAfee, RN, BSN, CNN Children’s Hospital of Seattle, Seattle, Wa Norma J Maxvold MD Pediatric Intensivist @DeVos Children’s Hospital, Grand Rapids, MI

18. Who are the faculty? Deborah Pasko PharmD Clinical Pharmacist, PICU, University of Michigan, Ann Arbor MI Andree V Gardner Supervisor of Administrator Services, DeVos Children’s Hospital, Grand Rapids, MI

19. Who are the faculty? John Gardner, BSN, RN Nurse Manager, Pediatric Nephrology @ DeVos Children’s Hospital, Grand Rapids, MI Michael Somers, MD Pediatric Nephrologist Boston Children’s Hospital, Boston MA

20. Thanks to our Supporters Arrow International Baxter Health Care B Braun Medical Dialysis Solution Inc Edwards Life Sciences Fresenius Medical Gambro Renal Products MedComp Inc Tyco/Kendall Healthcare

21. What is new this time? Addition of Workshops on Nursing by request Workshops by Industry by request Workshops on Drug monitoring by request Workshops on Nutrition by request Session on Bone Marrow Transplantation Session on Plasmapheresis

22. Who are the Audience 29 abstracts were submitted from 9 separate countries 50% make up of Nursing 45% physician 5% pharmacist

23. A few requests Ask questions.. we all learn Interact with others outside your program during the breaks, lunch Visit the booths learn what each machine, solution, and access can do for your program

24. A few requests Fill out your evaluation cards and hand them into the desk 11.5 CMEs 13.8 CEUs

25. Finally Have fun and open your mind This is a therapy that is still in development, the applications of these therapies are without boundaries If Carol Malone of I can help you in any way please do not hesitate to ask

26. Quote that I live by “the smartest one in the room is the child”