1. Healthgrid Systems Experiences from International Projects David MANSET Director of Biomedical Applications CEO MAAT France www.maat-g.com

2. IdeaDevelopmentStart-Up 1998- Stage 12000- Stage 2 2004- Stage 3 2007- Stage 4 Growth Foundation Process Virtual Knowledge & Maat Gknowledge Incubation, I+D+i, Raising Public Awareness Maat Gknowledge Internationalization Partners Network maat – Stages of Growth

3. maat Portfolio (1) Horizontal Solutions Data Warehouse Grid Integration SaaS

4. maat Portfolio (2) SMEs - ERP Vertical Solutions Banking Is about Core Banking - Integrated transactional banking system - CRM, - Wealth management, - Corporate banking, - Trade Finance, - Functional services Is about Core Banking - Integrated transactional banking system - CRM, - Wealth management, - Corporate banking, - Trade Finance, - Functional services Education Public Administration Is about e-Administration - Faciliate access to information, - Electronic access points, - Security and privacy on citizens data, - System interoperability, - eServices to citizens such as electronic transactions, - Compliant with LAECAP law Is about e-Administration - Faciliate access to information, - Electronic access points, - Security and privacy on citizens data, - System interoperability, - eServices to citizens such as electronic transactions, - Compliant with LAECAP law RAD Web Healthcare Is about Healthcare ICT - Research infrastructure, - Multi-level data integration, - Multi-centre network, - Security and privacy conformance, - Multi-backends abstraction, - DICOM compliant Is about Healthcare ICT - Research infrastructure, - Multi-level data integration, - Multi-centre network, - Security and privacy conformance, - Multi-backends abstraction, - DICOM compliant

5. Service Utility Service Utility Service Utility Knowledge Data Services GridGrid maat Portfolio (3)

6. An Inter-Disciplinary Middleware-Agnostic Web Operating System maat Portfolio (3) *Courtesy of SIEMENS

7. Awards in 1 Year Time.. maatGold Medal maat received a “Gold Medal” Award at the 2007 “Salon International des Inventions de Genève” Healthgrid Platform for its prototype Healthgrid Platform maatGold Medal maat received a “Gold Medal” Award at the 2007 “Salon International des Inventions de Genève” Healthgrid Platform for its prototype Healthgrid Platform HeC/maat 1st Best Live Demo HeC/maat ranked 1st Best Live Demo at the 2008 EGEE User Forum, February in Clermont-Ferrand, France for its Healthgrid Platform and Innovative Applications HeC/maat 1st Best Live Demo HeC/maat ranked 1st Best Live Demo at the 2008 EGEE User Forum, February in Clermont-Ferrand, France for its Healthgrid Platform and Innovative Applications HeC/maat Top 5 Best Live DemosRunners Up HeC/maat ranked in Top 5 Best Live Demos, qualified as “Runners Up” at the 2007 EGEE Conference last October Healthgrid Platform in Budapest, Hungary for its Healthgrid Platform HeC/maat Top 5 Best Live DemosRunners Up HeC/maat ranked in Top 5 Best Live Demos, qualified as “Runners Up” at the 2007 EGEE Conference last October Healthgrid Platform in Budapest, Hungary for its Healthgrid Platform HeC/maat 1st Best Live Demo HeC/maat ranked 1st Best Live Demo at the 2008 HealthGrid Conference, June in Chicago, US HeC/maat 1st Best Live Demo HeC/maat ranked 1st Best Live Demo at the 2008 HealthGrid Conference, June in Chicago, US HeC/maat Best Exhibit 1st Prize HeC/maat won Grand Prize - Best Exhibit 1st Prize at the 2008 ICT Conference, at the 2008 ICT Conference, November in Lyon, France  10’000€ HeC/maat Best Exhibit 1st Prize HeC/maat won Grand Prize - Best Exhibit 1st Prize at the 2008 ICT Conference, at the 2008 ICT Conference, November in Lyon, France  10’000€

8. Healthgrid (1) The Internet, the Web and the GRID Internet The worldwide network of networks... Web The protocol for sharing Information over the Internet... Grid The environment for sharing computing resources over the Web... *Courtesy of EGEE Project

9. Portal (A series of *web* interfaces exposing the functionality to end-users from login, to data acquisition, quality control, Workflow authoring... and much more! The Portal approach beyond accessibility advantages, allows harmonizing the software offer) Portal (A series of *web* interfaces exposing the functionality to end-users from login, to data acquisition, quality control, Workflow authoring... and much more! The Portal approach beyond accessibility advantages, allows harmonizing the software offer) Business Logic (NeuroSciences Specific Services) Business Logic (NeuroSciences Specific Services) Domain Logic (Medical Generic Services)‏ Domain Logic (Medical Generic Services)‏ Security (All services concerned with authentication, authorization within the neuGRID platform) Security (All services concerned with authentication, authorization within the neuGRID platform) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) System Architecture (1/2) Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, LONI, Oracle 11g...) Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, LONI, Oracle 11g...) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources, and from which higher level logic such as Provenance can extract useful historical data) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources, and from which higher level logic such as Provenance can extract useful historical data) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming with all other requirements, e.g. Security, privacy...) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming with all other requirements, e.g. Security, privacy...) Privacy (All services necessary to guaranty privacy Over medical data storage, access and Sharing. Privacy related services must conform with ethical EU/National regulations) Privacy (All services necessary to guaranty privacy Over medical data storage, access and Sharing. Privacy related services must conform with ethical EU/National regulations) Layered View & Concepts

10. Portal (A series of *web* interfaces exposing the functionality to end-users from login, to data acquisition, quality control, Workflow authoring... and much more! The Portal approach beyond accessibility advantages, allows harmonizing the software offer) Portal (A series of *web* interfaces exposing the functionality to end-users from login, to data acquisition, quality control, Workflow authoring... and much more! The Portal approach beyond accessibility advantages, allows harmonizing the software offer) Business Logic (NeuroSciences Specific Services) Business Logic (NeuroSciences Specific Services) Domain Logic (Medical Generic Services)‏ Domain Logic (Medical Generic Services)‏ Security (All services concerned with authentication, authorization within the neuGRID platform) Security (All services concerned with authentication, authorization within the neuGRID platform) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) Backends Abstraction (Software abstraction from databases, grid, enactment environments...) Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, LONI, Oracle 11g...) Backends Middleware (Underlying IT legacy assets, e.g. EGEE gLite, mySQL, LONI, Oracle 11g...) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources, and from which higher level logic such as Provenance can extract useful historical data) Monitoring, Logging and Accounting (Provides the mechanisms to store, archive and sort all log information. The layer is concerned with services which allow efficient monitoring of all infrastructure resources, and from which higher level logic such as Provenance can extract useful historical data) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming with all other requirements, e.g. Security, privacy...) Workflow Management (SOA Governance is in charge of defining, accessing, executing, operating and maintaining reusable services with appropriate quality of services and conforming with all other requirements, e.g. Security, privacy...) Privacy (All services necessary to guaranty privacy Over medical data storage, access and Sharing. Privacy related services must conform with ethical EU/National regulations) Privacy (All services necessary to guaranty privacy Over medical data storage, access and Sharing. Privacy related services must conform with ethical EU/National regulations) Layered View & Concepts Generic to ALL domains (can theoretically be fully reused) Generic to Medical domain (can theoretically be reused in other medical applications) Specific to Project (can theoretically be partly reused since abstracted from underlying IT) Common Purpose Interfaces Highly Specialized Interfaces System Architecture (2/2)

11. Mammogrid+ A Grid-powered Mammography Database Healthgrid (1) Healthgrid Second Opinion Cancer Screening Education and Training Reference Database / Repository

12. neuGRID A Grid-based e-Infrastructure for Data Archiving and Computing Intensive Applications in neurosciences Healthgrid (2) Question A Marker of Alzheimer’s progression? Healthgrid Biomarkers Assessment Biomarkers Authoring Extension to Other Medical Areas Reference Database & Infrastructure

13. Pharmaco-Epidemiology Multi-centre Pharma Grid-based Data Warehouse for Epidemiological Studies Healthgrid (3) Healthgrid Epidemiological Studies Scalable Dataware House Scalable Statistical Analysis Translational Research Reference Database

14. Health-e-Child, An Healthgrid for Paediatrics Healthgrid (4) Cardiology Tetralogy of Fallot (ToF) Cardiomyopathy (HCM, DCM) Rheumatology Juvenile Idiopathic Arthritis (JIA) NeuroOncology Brain Tumors – Gliomas Healthgrid Decision Support Vertical Data Integration Knowledge Discovery Reference Database of Rare Conditions

15. SENTINELLE Network Breast and Colon Cancer Screening, Surveillance Network Healthgrid (5) Healthgrid Breast Cancer Screening Colon Cancer Screening Surveillance, Alert and Monitoring Network

16. SPIDeR Super Peta-scale Infrastructure for Distributed e-health and biomedical Research Healthgrid (6) Healthgrid Neurology Epidemiology Drug Development http://spider.healthgrid.org Silken Bags Silk Collaborations SPIDeR Web A Super Infrastructure of about - 6000 CPUs, - 100TB, - 15 new dedicated sites

17. GOSH UWE IGG SIEMENS ASPER UOA INRIA LYNKEUS UCL EGF FGG MAAT Clinical Site R&D Site + DISI INDRA PRODEMA CERN KI VUmc CETA CIEMAT HG CFC Infrastructure + MAAT NECKER FBF + + + OPBG + + + JHU SIEMENS + + MAAT COL +

18. Healthgrid DSS Paediat. CancerAlzheimer Biomarker CADe Breast Cancer 200620052008 UWE Mammogrid+Health-e-ChildneuGRID + + + + + Healthgrid Marketing Plan (1)

19. Marketing Plan (2) Healthgrid + + + + + DSS Paediat. Cancer Alzheimer Biomarker CADe Breast Cancer Certified Partners A Network of Certified Partners - Support in porting new applications to HGSP - Online & Offline education services - OnDemand infrastructure and data for application training - Access to infrastructure facilities for promoting new products - Direct access to market (i.e. Network of Clinical Institutions) - Certification process and official label for software - Possibility to sell online consultancy - Education careers: technicial (presales, maintenance and support, and operation) and sales/marketing Clinical Institutions A Network of Clinical Institutions - User Support - Online & Offline Education Services (from HGSP and from Certified Partners) - Access to a large network of excellence at minimal cost - Access to state-of-the-art software from Certified Partners - Provide data for enriching the infrastructure Infrastructure - Teaming-up with Telco Operators (i.e. Telefonica) - Sustainable platform and infrastructure - Strong position in the market and its big sales network (not only in Spain but worldwide) - Opened infrastructure to Consultancy and Systems Integrator firms (i.e. Indra, Entel) + THANK YOU FOR YOUR ATTENTION!