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William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 22 Applications and Ethics of Biotechnology Copyright © 2006 Pearson Prentice Hall, Inc.
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Biotechnology Has Revolutionized Agriculture Transgenic Crops and Herbicide Resistance
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Figure 22-1 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-2 Copyright © 2006 Pearson Prentice Hall, Inc.
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Nutritional Enhancement of Crop Plants
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Figure 22-3 Copyright © 2006 Pearson Prentice Hall, Inc. “Golden Rice” High levels of β-carotene
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Concerns about Genetically Modified Organisms
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Pharmaceutical Products Are Synthesized in Genetically Altered Organisms Insulin Production in Bacteria
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Figure 22-4 Copyright © 2006 Pearson Prentice Hall, Inc.
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Table 22-1 Copyright © 2006 Pearson Prentice Hall, Inc.
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Pharmaceutical Products Are Synthesized in Genetically Altered Organisms Transgenic Animal Hosts and Pharmaceutical Products
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Figure 22-5 Copyright © 2006 Pearson Prentice Hall, Inc.
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Transgenic Plants and Edible Vaccines (“subunit vaccines”)
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Figure 22-6 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-7 Copyright © 2006 Pearson Prentice Hall, Inc.
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Biotechnology Is Used to Diagnose and Screen Genetic Disorders
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Figure 22-8 Copyright © 2006 Pearson Prentice Hall, Inc. 15 -20 weeks
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10 -12 weeks
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Prenatal Diagnosis of Sickle-Cell Anemia
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Figure 22-9 Copyright © 2006 Pearson Prentice Hall, Inc.
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Nucleotide Polymorphisms and Genetic Screening Allele-specific oligonucleotides
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Figure 22-10 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-11 Copyright © 2006 Pearson Prentice Hall, Inc.
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DNA Microarrays
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Figure 22-12 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-13 Copyright © 2006 Pearson Prentice Hall, Inc.
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Gene expression profiling
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Figure 22-14 Copyright © 2006 Pearson Prentice Hall, Inc.
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Disease Diagnosis
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Figure 22-15 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-16 Copyright © 2006 Pearson Prentice Hall, Inc.
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Genome Scanning
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Figure 22-17 Copyright © 2006 Pearson Prentice Hall, Inc.
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Genetic Testing and Ethical Dilemmas
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Genetic Disorders Can Be Treated by Gene Therapy
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Figure 22-18 Copyright © 2006 Pearson Prentice Hall, Inc.
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Gene Therapy for Severe Combined Immunodeficiency (SCID)
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Figure 22-19 Copyright © 2006 Pearson Prentice Hall, Inc. Ashanti De Silva
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Figure 22-20 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-21 Copyright © 2006 Pearson Prentice Hall, Inc.
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Problems and Failures in Gene Therapy
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Science 2003 302: 415-419
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Future of gene therapy? Table 22-2 Copyright © 2006 Pearson Prentice Hall, Inc.
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Gene Therapy Raises Many Ethical Concerns Somatic versus germ-line “Common good” versus individual benefit Enhancement gene therapy
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Ethical Issues Are an Outgrowth of the Human Genome Project The Ethical, Legal, and Social Implications (ELSI) Program http://www.ornl.gov/sci/techresources/Human_Genome/elsi/elsi.shtml
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Finding and Mapping Genes in the Human Genome with Recombinant DNA Technology RFLPs as Genetic Markers
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Figure 22-22 Copyright © 2006 Pearson Prentice Hall, Inc.
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Linkage Analysis Using RFLPs
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Figure 22-23 Copyright © 2006 Pearson Prentice Hall, Inc.
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Finding and Mapping Genes in the Human Genome with Recombinant DNA Technology Positional Cloning: The Gene for Neurofibromatosis
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Figure 22-25 Copyright © 2006 Pearson Prentice Hall, Inc. Neurofibromatosis
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DNA Fingerprints Can Identify Individuals Minisatellites (VNTRs) and Microsatellites (STRs)
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Figure 22-27 Copyright © 2006 Pearson Prentice Hall, Inc.
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Figure 22-28 Copyright © 2006 Pearson Prentice Hall, Inc.
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Forensic Applications Paternity testing
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November 21, 2005 Article 1 Preimplantation Genetic Diagnosis (PGD) Article 2
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That’s All!
