1. Chapter 6 Gene Prediction: Finding Genes in the Human Genome

2. Figure 6.1: Map of the human X-chromosome

3. Figure 6.2: Schematic view of a typical prokaryotic gene and the mRNA transcribed from the gene

4. Figure 6.3: Transcriptional units in prokaryotes (A) can contain multiple open reading frames; eukaryotic transcriptional units (B) can have only one ORF each

5. Figure 6.4: The eukaryotic promoter, defined by an assemblage of interacting protein transcription factors bound to DNA

6. Figure 6.5: A eukaryotic mRNA is processed by splicing after transcription to remove introns and join exons into a continuous coding sequence

7. Figure 6.6: Consensus promoter sequences based on a few strong E. coli promoters

8. Figure 6.7: The six possible reading frames within a short piece of double- stranded DNA

9. Figure 6.8: Output from NCBI’s ORF Finder program Courtesy of ORF/National Center for Biotechnology Information

10. Figure 6.T1: Promoter sequences recognized by some E. coli sigma factors

11. Figure 6.T2: One-letter code for ambiguous nucleotides

12. Figure 6.9: The splicing process and consensus sequences at the exon- intron boundaries and branch site

13. Figure 6.T3: Codon usage table for human genes