1. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 1 PopMedNet in the pSCANNER Network PMN User Meeting

2. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 2 pSCANNER Network – 16M patients 5 University of California Medical Centers Cedar’s Sinai Hospital Pacific NW Rural Health Practice-Based Research Network Los Angeles Department of Health Services Intermountain Health Care 5 multi-site FQHCs Children’s Hospital of Los Angeles Keck Medicine of USC

3. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 3  Service Oriented Architecture for privacy-preserving analytics in distributed research networks › Focus on map-reduce, iterative algorithms based on parallel- distributed processing algorithms  Role based access control  De-centralized study administration  Menu-driven queries for multiple activities › Proposing collaboration partners, data sets, and protocols › Specifying regression analytics › Data set extractions › Cohort discovery  Methods repository for contributing analytic methods SCANNER Network Software (AHRQ 2010-2014)

4. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 42015

5. 5 Traditional 3-tier Architecture

6. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 6 Data Tier Local Logic Tier Code & Specification Repository (1)PRESENTATION (2)TRANSLATION (3)AGGREGATION (4)STORED SPECIFICATIONS Aggregation Logic Tier This layer coordinates across results produced by multiple sites. (1)Aggregate for Display (2)Aggregate for Iteration Translation Logic Tier (DAN) TBD whether this happens locally or as a service (OR BOTH). This layer reads metadata from each site and translates platform independent specifications into platform-specific executables ASSEMBLE PROGRAM S STANDARDIZE OUTPUT Authorization Tier Local authorities verify (may be automated, pre-authorized, or manual) (1)Validity of Localization (2)Access Permission (3)Verity of Results Authorize Verify Authorize Verify Authorize Verify Authorize Verify Authorize Verify Authorize Verify GLOBAL LOCAL New in pSCANNER-PMN

7. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 7  Replace pSCANNER role-based access controls with PopMedNet API  Replace pSCANNER methods repository with GitHub for open source analytics › Collaboration with CEILO social code-sharing platform  Platform-independent, ISO & HL7 standards-based query formats  Replaces pSCANNER nodes’ web API with modified PopMedNet DataMartClient & pSCANNER Request Types  Adding features to PopMedNet › New PMN permission type – any investigator can propose a study to any site, any site can decline or agree to participate › New PMN node that aggregates results and re-issues requests New in pSCANNER Software

8. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 8 Menu-driven Queries for Compatible Analytic Libraries Data Visualization (Observational Health Data Science & Informatics) Electronic Clinical Quality Measures (NQF Library) Privacy-preserving Multivariate Map-Reduce (One Model Per Network) Independently Estimated Multi-Variate (One model per site) Model Transformation Libraries OMOP CDM to PCORnet CDM OMOP CDM to CMS Quality Data Model Version control of local EHR DBs to CDMs Study-Specific Dataset ETLs Open Source Code Repository Code & Specification Repository (1)PRESENTATION (2)TRANSLATION (3)AGGREGATION (4)STORED SPECIFICATIONS

9. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 9 2016 - Stakeholders & Partners CIELO: “Towards a research analysis commons” OHDSI: “To transform medical decision making …health databases for population-level estimation and patient-level predictions” PCORNet: “fosters a range of observational and interventional research that harnesses the power of clinical data gathered at the point of care in health systems across the country.” National Quality Forum: “…National collaboration to improve health and healthcare quality through measurement”

10. Supported by the Patient-Centered Outcomes Research Institute (PCORI) Contract CDRN-1306-04819 10