1. INIBITORI DELLACETILCOLINESTERASI (AChE) 1) reversibili, legame non covalente

2. INIBITORI DELLACETILCOLINESTERASI (AChE) 2a) reversibili, legame covalente

3. INIBITORI DELLACETILCOLINESTERASI (AChE) 2b) reversibili, legame covalente

4. DFP (DIIDROPROPILFLUOROFOSFATO) PARATHION MALATHION CLORPIRIFOS INIBITORI DELLACETILCOLINESTERASI (AChE) 3a) irreversibili: insetticidi organofosforici

5. INIBITORI DELLACETILCOLINESTERASI (AChE) 3b) irreversibili, gas nervini

9. Anti-AChR antibodies cross-link AChRs Cross-linked AChRs are endocytosed more rapidly than normal Internalized AChRs are degraded Fewer AChRs remain on the Post-Junctional membrane RESULT: Less efficient neuromuscular transmission

10. Complement binds to the Antibody-AChR complex Membrane-attack complex (MAC) forms on the membrane The post-junctional membrane is damaged Fewer post-synaptic membrane folds Reduced numbers of AChRs Widened synaptic cleft RESULT: Less efficient neuromuscular transmission