1. Wheezing in Young Children Is it Bronchiolitis or is it Asthma???

2. Bronchiolitis Bronchiolitis is an infectious, self-limited disease. Its therapy is based on supportive care, oxygenation, hydration, and fever control. The pathology results in obstruction of bronchioles from inflammation, edema, and debris, leading to hyperinflation, increased airway resistance, atelectasis, and ventilation-perfusion mismatching (decreased O2 saturations) Bronchoconstriction has not been described.

3. Bronchiolitis Despite the prominent role that inflammation plays in the pathogenesis of airway obstruction, corticosteroids have not proven beneficial in improving clinical status in several large, controlled multi- institutional studies. American Academy of Pediatrics - Diagnosis and Management of BronchiolitisDiagnosis and Management of Bronchiolitis

4. Asthma Predictive Index (API) Developed from a large longitudinal study from the Tuscon Children ’ s Respiratory Study which identified 3 groups of children who wheeze: »Early wheezers »Late onset wheezers »Persistent wheezers –API developed to differentiate “ Early wheezers ” from “ Persistent wheezers ” or children who will develop asthma API is the basis for the NHLBI recommendations for Initiating Long-term Controller Therapy in Young Children (0-4 years) The Asthma Predictive Index: a very useful tool for predicting asthma in young children.Source:Journal of allergy and clinical immunology [0091-6749] Castro Rodriguez, Jose yr:2010 vol:126

5. NHLBI Guidelines for Initiating Long-term Controller Therapy in Young Children (0-4 years) To reduce impairment in children who have: –1) 4 or more episodes of wheezing in the past year »Wheezing lasted more than 1 day »Affected sleep »Risk factors for the development of asthma 1 of the following: –Parental history of asthma OR –Physician diagnosed atopic dermatitis –Evidence of sensitization to aeroallergens OR 2 of the following: –Evidence of food allergy –Wheezing apart from colds –Peripheral blood eosinophilia (> 4%)

6. Initiating Long-term Controller Therapy in Young Children (0-4 years) To reduce impairment in children who have: 2) Consistently required symptomatic treatment (reliever) more than 2 times/week for greater than 4 weeks Should be considered for reducing risk in infants and young children who have 2 exacerbations requiring systemic steroids within 6 months

7. Asthma Therapy in Children 0-4 Years Treatment is often in the form of a therapeutic trial –Monitor response over 4-6 weeks »If no response, stop therapy and reevaluate for other diagnosis »If a clear positive response for at least 3 months (good asthma control) step down as tolerated