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Carboxylic Acid Derivatives Acid Chlorides Acid Anhydrides Esters Amides Nitriles Nucleophilic Acyl Substitution
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Reactivity of Acid Derivatives
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Nucleophilic Acyl Substitution
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I.U.P.A.C. Nomenclature ( uses carboxylic acid template)
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Acid Chlorides
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Acid Anhydrides
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Esters
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Amides
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Lactones (cyclic esters)
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Gamma Hydroxybutyrate
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All Acid Derivatives can be Hydrolyzed
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What are the 3 Hydrolysis Products?
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Draw the Hydrolysis Products
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Hydrolysis of Penicillin
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Aspartame
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Hydrolysis of an Acid Chloride
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Acid Chloride Preparation
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Nucleophilic Acyl Substitution
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With Acid Chlorides, No Catalyst is Needed Anhydride Prep.
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Ester Preparation from an acid chloride
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Amide Preparation from an Acid Chloride
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Amide from Anhydride
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Fischer Esterification
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Fischer Esterification Shows Oxygen “Scrambling” a methanolysis
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Diazomethane Preparation of Methyl Esters
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Diazomethane has a Basic Carbon
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Mechanism
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Flavors and Fragrances
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Intramolecular Fischer Esterification - GHB
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Lactam (cyclic amide) Formation
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-Lactams as Antibiotics
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Acid Catalyzed “Olysis” Reactions
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Transesterification a Methanolysis
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Aspirin Synthesis
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Basic Hydrolysis Saponification
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Basic Hydrolysis of an Amide
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Mechanism
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Reduction of Esters with LiAlH 4
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DIBAH Diisobutyl Aluminum Hydride
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