1. M endel‘s Law of Segregation

2. Georg Mendel Austrian monk born in 1822 in monastery known for research and teaching after his death (1884) acknowledgment of his discoveries in 1900

3. Experiments with Pea Plants - Seed coat colour (gray or white) - Seed shape (round or wrinkled) - Seed colour (yellow or green) - Pod colour (green or yellow) - Flower position (axial or terminal) - Pod shape (inflated or constricted) - Stem length (tall or dwarf)

4. Cross-Pollination of Purebread Plants - cross-pollination between true breeding green and yellow pods - all F1 green F1 Generation Gg = heterozygous

5. F2 Generation - self-pollination of green F1 plants - ¾ in F2 green, ¼ yellow - 3 : 1 ratio in pod colour in F2 G = dominant = green g = recessive = yellow GG, gg = homozygous

6. Seed Colour C = dominant = yellow c = recessive = green

7. Inheritance of Pea Colour phenotype: genotype:

8. Results from Mendel's Experiments Parental Cross F 1 Phenotyp e F 2 Phenotypic Ratio F 2 Ratio Round x Wrinkled Seed Round 5474 Round : 1850 Wrinkled 2.96:1 Yellow x Green Seeds Yellow 6022 Yellow : 2001 Green 3.01:1 Axial x Terminal Flower Position Axial 705 Axial : 224 Terminal 3.15:1 Tall x Dwarf Plants Tall l787 Tall : 227 Dwarf 2.84:1

9. Mendel‘s Generalization 1.Alternative versions of genes account for variations in inherited characters - concept of alleles (G=green, g=yellow) 2. For each character, an organism inherits two genes, one from each parent - two gametes form somatic cells - one allele comes from the mother, one from the father

10. 3. If the two alleles differ, then: - dominant allele is fully expressed in the organism's appearance (phenotype) - recessive allele has no noticeable effect on the organism's appearance (genotype) 4. The two genes for each character segregate during gamete production - ensures variation Mendel‘s Generalization

11. Law of Segregation the pair of alleles of each parent separate and only one allele passes from each parent on to an offspring which allele in a parent's pair of alleles is inherited is a matter of chance segregation of alleles occurs during the process of gamete formation (meiosis) randomly unite at fertilization

12. Mendel’s laws have their limitations. For example, if two genes are on the same chromosome, the assortment of their alleles will not be independent. Also, for genes found on the X chromosome, expression of the trait can be linked to the sex of the offspring. Our knowledge of genetics and the tools we use in its study have advanced a great deal since Mendel’s time, but his basic concepts still stand true.

13. Drosophila melanogaster, the common fruit fly, has been used for genetic experiments since T.H. Morgan started his experiments in1907. Drosophila make good genetic specimens because they are small, produce many offspring, have easily discernable mutations, have only four pairs of chromosomes, and complete their entire life cycle in about 12 days. They also have very simple food requirements. Chromosomes 1 (the X chromosome), 2, and 3 are very large, and the Y chromosome – number 4 – is extremely small. These four chromosomes have thousands of genes, many of which can be found in most eukaryotes, including humans.

14. Differences in body features help distinguish between male and female flies. Females are slightly larger and have a light-colored, pointed abdomen. The abdomen of males will be dark and blunt. The male flies also have dark bristles, sex combs, on the upper portion of the forelegs.