1. REDUCING MERCURY EXPOSURE FROM FISH IN THE GREAT LAKES Nathan Reynolds Introduction to Nutrition IMPH 2013-2014

2. GEOGRAPHICAL CONTEXT  Comprised of 5 Lakes Superior, Michigan, Huron, Erie and Ontario  1/5 of the world’s fresh water  Bound by 8 States and 1 Province  Minnesota, Wisconsin, Illinois, Indiana, Michigan, Ohio Pennsylvania and New York  Ontario

3. HISTORY Steam ships started navigating the Great Lakes waterways in 1816 Initially transported timber, fur, grain, meat products, dairy, minerals, copper By the late 19 th and 20 th century, the Great Lakes region was known as the “Industrial Belt” of America Heavy metal mining, automobile manufacturing, steel smelting and oil refining were integral parts of the economy Utilized steam ships and coal-powered locomotives to carry products to New England Mercury as a waste product

4. MERCURY TRENDS IN GREAT LAKES Source: McGoldrick, D., Clark, M., and Murphy, E. 2012. "Contaminants in Whole Fish", In: U.S. EPA and Environment Canada. 2012. State of the Great Lakes 2012

5. BIOMAGNIFICATION The tendency for the concentration of a substance to increase based on food chain energetics and life longevity of species Predatory Great Lake Fish types Lake Trout Brown Trout Bass Walleye

6. AVERAGE PPM OF MERCURY IN POPULAR SPORT FISH Source: University of Toledo. www.eng.utoledo.edu/aprg/courses/dm/risk/tablefigmercpaper.pdf Moderate High

7. HEALTH HAZARDS  Once contaminated fish are consumed, methylmercury is readily absorbed. It binds to L-Cysteine, forming a Methylmercury-Cysteine (MeHg-Cys) conjugate, which can easily translocate the Blood-Brain Barrier via amino acid carriers  Accumulation of mercury in neural tissue  Passes through placenta to developing fetus and can cause Cognitive impairment, primitive reflexes and hyperkinesia  Exposure in infants and children can cause Poorer neurological status, impaired development, impaired motor skill development Source: Kerper LE, Ballatori N and Clarkson TW. Methylmercury transport across the blood-brain barrier by an amino acid carrier. Am J Physiol. 1992;262(5 pt2):R761-5. Mergler D, Anderson HA, Chan LHM, Mahaffey KR, Murray M, Sakamoto M and Stern AH. Methylmercury Exposure and Health Effects in Humans: A Worldwide Concern. Royal Swedish Academy of Sciences. 2007; 36(1):3-11.

8. RISK GROUP Estimated Number of individuals that consume >104 meals of Great Lakes fish per year StateEstimated Illinois 376,000 Indiana 161,000 Michigan 324,000 Minnesota 107,000 New York 1,054,000 Ohio 352,000 Pennsylvania 342,000 Wisconsin 140,000 Total 2,856,000.00 Source: Imm P, Knobeloch L, Anderson HA and the Great Lakes Sport Fish Consortium. Fish Consumption and Advisory Awareness in the Great Lakes Basin. Environ Health Perspect. 2005;113(10):1325 - 1329 Source: Environmental Protection Agency. Trends in Blood Mercury Concentrations and Fish Consumption Among U.S. Women of Childbearing Age NHANES, 1999- 2010. 2013. Distribution of blood THg (μg/L), by reported frequency of fish consumption in 30 days, women aged 16-49 years, NHANES 1999-2010

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