1. Maša Radeljak Mentor: A. Žmegač Horvat
TREATMENT OF TUMORS
Maša Radeljak
Mentor: A. Žmegač Horvat

2. GOALS OF TREATMENT Complete removal Palliation
Amelioration of symptoms
Preservation of quality of life

3. TREATMENT OF TUMORS Surgery Radiation therapy Chemotherapy
Biologic therapy

4. TREATMENT OF TUMORS ADJUVANT Given after the primary treatment
Chemotherapy, radiation therapy, biologic therapy
NEOADJUVANT
First step before the main treatment
Chemotherapy, radiation therapy

5. SURGERY Prevention- resection of premalignant lesions
Diagnosis- excisional biopsy, incisional biopsy, core-needle biopsy, fine-needle aspiration

6. SURGERY
Staging- determining the extent of the disease and whether it has metastasized to regional lymph nodes

7. SURGERY - TREATMENT Most effective therapy 40% Complete excision
Local control of tumor
Preservation of organ function
Resection of metastatic disease
Staging information
Mastectomy, prostatectomy, lung cancer surgery

8. SURGERY
Palliation- supportive care, pain management, insertion of central venous catheters, ascites
Rehabilitation- breast reconstruction, orthopedic procedures

9. RADIATION THERAPY Target tissue Genetic material Free radicals Oxygen
X-rays and gamma rays
Teletherapy, brachytherapy, systemic therapy with radionuclides

10. TELETHERAPY External beam radiotherapy Linear accelerators
Most commonly used form of radiation
Breast, head and neck cancer, Hodgkin's disease

11. BRACHYTHERAPY Internal radiotherapy Inside or next to the tumor
Temporary or permanent
Cervical, brain, skin and prostate cancer

12. CHEMOTHERAPY Cytotoxic drugs Rapidly dividing cells Alkylating agents
Antimetabolites
Plant alkaloids and terpenoids
Topoisomerase inhibitors
Antitumor antibiotics
Hormonal agents

13. TOXICITY Nausea Vomiting Myelosuppression Mucositis Alopecia
Gonadal dysfunction

14. BIOLOGIC THERAPY Immune mediators Antibodies Cytokines
Angiogenesis inhibitors

15. REFERENCES http://en.wikipedia.org/wiki/Cancer_treatm ent
Harrison: Principles of Internal Medicine