1. Sorting Out Antibiotics: A systematic approach to antibiotic selection Kenneth Alexander, M.D., Ph.D. Associate Professor of Pediatrics and Microbiology Duke University Medical Center Durham, North Carolina

2. Agents for Infections Due to Gram Positive Bacteria
Staph. epidermidis
MRSA
Staph. aureus
(Group A and Group B)
Streptococci
GNR
RGNR
Pseudomonas aeruginosa
Penicillin G
Penicillin V
Methicillin, Oxacillin, Nafcillin, Cloxacillin
Dicloxacillin, Cloxacillin
Vancomycin
Dalfopristin/Quinopristin, Linezolid, Daptomycin
Linezolid

3. Broad and Extended Spectrum Penicillins
Staph. epidermidis
MRSA
Staph. aureus
(Group A and Group B)
Streptococci
GNR
RGNR
Pseudomonas aeruginosa
Ampicillin
Amoxicillin
Carbenicillin, Mezlocillin, Piperacillin, Ticarcillin
Ampicillin + Sulbactam = Unasyn®
Amoxicillin + Clavulanic Acid = Augmentin®
Ticarcillin + Clavulanic Acid = Timentin ®, Piperacillin + Tazobactam = Zosyn®

4. Cephalosporins 1st Generation 2nd Generation 3rd Generation
Staph. epidermidis
MRSA
Staph. aureus
(Group A and Group B)
Streptococci
GNR
RGNR
Pseudomonas aeruginosa
Cefazolin
1st Generation
Cephalexin, Cefadroxil
Cefuroxime, Cefoxitin
Cefaclor, Loracarbef, Ceftibuten
Cefprozil, Cefuroxime axetil, Cefpodoxime, Cefdinir
2nd Generation
Ceftriaxone, Cefotaxime
Cefixime
3rd Generation
Ceftazidime
Cefepime
4th Generation

5. Macrolides, Azalides and Ketolides
Staph. epidermidis
MRSA
Staph. aureus
(Group A and Group B)
Streptococci
GNR
RGNR
Pseudomonas aeruginosa
Erythromycin
Azithromycin
Clarithromycin, Azithromycin, Telithromycin

6. Broad Spectrum Antibiotics
Staph. epidermidis
MRSA
Staph. aureus
(Group A and Group B)
Streptococci
GNR
RGNR
Pseudomonas aeruginosa
Gentamicin, Tobramycin, Netilmicin, Amikacin
Trimethoprim/Sulfamethoxazole
Trimethoprim/Sulfamethoxazole
Tetracycline, Doxycycline, Minocycline
Tetracycline, Doxycycline, Minocycline, Tigecycline
Ciprofloxacin, Levofloxacin, Moxifloxacin, Gatifloxacin
Ciprofloxacin, Levofloxacin, Moxifloxacin, Gatifloxicin
Imipenem, Meropenem, Ertapenem