1. Chapter 4 Priorities: An Organization Chart of the Body

2. Organization Cells Tissues Organs Organ Systems The Body

3. Specialized Functions Digestive System: food in / solid waste out Liver Respiratory System: gas exchange, O 2 in / CO 2 out Excretory System: Nitrogen and other soluble waste out, water, ion, and blood pressure balance Immune System: protection from invaders

4. Specialized Functions Cont. Circulatory System: Delivering things around the body Storage: Liver, muscle, fat and bone Reproductive System: A priority of the species Nervous System: Controls the endocrine system and expresses its priority

5. Priorities One individual (function) is more important than another Discrimination Priorities are necessary because resources are limited and circumstances change

6. Change Requires Adjustment Gravity Food and water Temperature Danger etc

7. Expression of Priorities Access to blood, access to resources

8. Sensitivity to Blood Flow Brain: acutely sensitive Heart: also acutely sensitive Kidney Digestive system Skin Liver and digestive system

9. Controlling Priorities

10. Barriers of the Body The interfaces with the outside world Exchange of atoms, molecules and heat Lungs Skin Digestive System

11. Barriers of the Body Constant replacement Damage repair Immune protection

12. The Lungs  A passive bag with a large blood supply  When skeletal muscles expand the chest, air is sucked into the lungs Gas Exchange

13. Diffusion A corollary of “Mother Nature’s Chaos” rule Everything goes downhill From a high concentration to a low concentration Concentration is the number of molecules (or ions) of a certain type per volume of water

14. Control of Breathing The brain controls how often the chest is expanded and how much the chest is expanded Information in: H + concentration, also acute stress override Information out: Motor nerves to the diaphragm and intercostal muscles The brain must tell you to breath every time

15. Airways The autonomic nervous system (part of the brain) controls the opening and closing of the airways and the flow of blood to the lungs Parasympathetic (calm times): closes airways and reduces blood flow Sympathetic (acute stress): opens airways and increases blood flow Immune protection

16. Skin The surface of the body Constant replacement and damage repair Heat exchange, large variations in blood flow Molecules can also pass into the blood through the skin eg. drugs, toxic molecules Immune protection

17. Skin Heat Exchange and water conservation also effects blood pressure Parasympathetic: more blood Sympathetic: less blood

18. Digestive System Digestion: Big molecules into little molecules Absorption: Taking the little molecules and ions into the body. Inside the digestive system is outside the body Immune protection

19. A “Captured” water Environment Compartmentalized Esophagus Stomach Small intestine Large intestine

20. Control of Digestion Parasympathetic: Increase movement, secretions, and blood flow Sympathetic: Decrease movement, secretions and blood flow The changes in blood flow are very large Priority of digestion is very low

21. The Liver and Kidney Liver:Adjusting the molecular composition of the blood Kidney: Water and ion balance

22. The Liver Blood containing nutrients taken into the blood at the small intestine goes directly to the liver through the hepatic portal vein Capillary bed Small intestine (in)Liver (out)

23. Liver Nutrients that enter the blood at the small intestine must get out of circulation in the liver before entering general circulation The liver has the first opportunity to store The liver also has the first exposure to drugs and toxic compounds More immune protection

24. Control of Liver Parasympathetic: promotes storage and increased flow of blood from the small intestine to the liver Sympathetic: Removes from storage and reduces blood flow from the small intestine to the liver Almost all hormones

25. Liver: Storage and Molecular Processing Blood also enters the liver from general circulation Nutrients enter the general circulation in the liver Molecules in general circulation are removed for reprocessing Many serum proteins and fats are made in the liver and released into circulation (eg. steroid binding proteins and cholesterol)

26. Balance:Ions and water Ion concentration Blood Pressure The ion concentrations of the blood must be “just right” The more water in the body, the higher the blood pressure The kidney controls the loss of water and ions from the body

27. Pressure and Volume When blood volume increases, blood pressure increases If you put in or remove ions from the body you must save or lose water to maintain concentrations “just right” The most important ion in this game is Na + H 2 0 mover faster and easier than Na +

28. Kidney Ion, water and blood pressure balance

29. Control of the Kidney Parasympathetic: Increases blood flow to the kidney and increases urine volume Sympathetic: Reduces blood flow to the kidney and decreases urine volume Hormones –Antidiuretic Hormone (ADH) from the pituitary: increases water recovery –Mineralocorticoids from the adrenal: increases ion recovery

30. Storage We live in a world of feast and famine We store when nutrients are available and remove from storage when not available All tissues except for the brain store to some extent The liver stores sugar for the brain

31. Storage Tissues for the General Body Muscle: amino acid storage Fat: Fat Bone: Calcium (Ca ++ ) In addition to the liver

32. Skeletal Muscle Movement of the skeleton is the only way that the brain can act on the world Generation of heat is a by-product of movement: makes you warm-blooded

33. Skeletal Muscles Composed of thousands of individual fibers that shorten when sent a signal by a nerve Each fiber is controlled by a single motor nerve One motor nerve can control many fibers There are two types of fibers –Tonic: deals with gravity –Phasic: Deals with movement

34. Skeletal Muscle continued Most muscles are composed of a mixture of both types of fibers. Most muscles carry out both functions: movement and posture (gravity) Tonic fibers work more because gravity is always present The two types of fibers respond to some signals differently

35. Control of muscle Both respond to signals from their motor nerve by shortening Sympathetic nervous system and adrenalin –Phasic more efficient –Tonic less efficient If you are in danger you don’t want posture getting in the way!!!

36. Hormonal Control Glucocorticoids: Shifts muscle into net degradation of proteins to provide amino acid carbon for making sugar in the liver and kidney- Phasic fibers more sensitive than tonic because they work less Insulin: Allows the fibers to take up sugar and amino acids- Tonic fibers more sensitive because they work more

37. Other Hormones Thyroid hormone: increases production and use of energy Growth hormone: Builds up muscle Testosterone: Makes exercise more useful in building up muscle

38. Fat Cells. OIL AND WATER DON’T MIX!

39. Control of Fat Cells Insulin: Uptake of nutrients- converts sugar to fat Adrenaline: release fat into circulation Many Drugs mobilize fat

40. Fat also produces hormones Adiponectin, Leptin, cytokines Obesity Diabetes Athrosclerosis

41. Distribution of Fat in the Body Are you a good fat or a bad fat? HDL LDL Oil and water don’t mix so fat must be packaged in a charged protein coat to move in the blood High Density Lipoprotein Low Density Lipoprotein

42. Bone Rigid structure against gravity – what muscles move All blood cells are born in the marrow of bones Storage of Calcium (Ca ++ )

43. Control of Bone Glucocorticoids: Demineralizes bone- More use less sensitive, less use more sensitive Calcitonin: From thyroid gland Ca ++ out of bone Parathyroid hormone: From parathyroid gland Ca ++ into bone storage

45. Control of Blood Cells Red Blood Cells: Erythropoietin controls how fast they are made in bone marrow White Blood Cells: –Insulin controls the uptake of nutrients –Glucocorticoids suppress –Cytokines: the chemical messages of the immune system (many effects)

46. A priority of the species Very expensive, especially to the female “Mother Nature” built the compulsion to do it into the brain We couple trading genetic material with reproduction

47. Change is Stress Stress requires adjustments Priorities are expressed in response to stress –Gravity –Starvation –Cold –Danger/anger

48. Drugs influence Priorities Coffee Nicotine and cocaine Alcohol Antihistamines Birth control pills Etc.