Information out from the brain >Blood flow to the surface of the body >Heat generation by the muscles >Behavior: “Are you smart enough to come in out of the cold”?
Why is Heat Important? 106° F: Fried Brains 86 ° F: Dysfunctional Brain unable to warm its self Rate of reactions is a function of temperature Reactions are energy transfer among molecules Too much heat destroys large molecules
Hemoglobin >Binds O 2 >The concentration of O 2 controls the ability of Hb to bind O 2 Only free O 2 plays in the concentration game Only free CO 2 plays in the concentration game Molecules flow from a high concentration to a low concentration
Sinks A sink is a way to remove O 2 and CO 2 from the concentration game Oxygen sink 2O 2 + Hb HbO 4 Carbon Dioxide Sink CO 2 + H 2 O H 2 CO 3 H + + HCO 3 -
Tissues: Gas exchange Water around cells Blood in capillary
Control of Respiration You only inhale if your brain tells you to Information in: H + concentration of the blood going to your head Your brain is responding to H + not O 2 Information out: Nerve signals to your diaphragm and intercostal muscles
Problems with Digestion Excessive stomach acid –Mild: heartburn –Severe: ulcers Drugs Antacids: H + + OH - H 2 O, disturbs blood pH, acid rebound Tagamet, Pepcid etc: Antihistamine that blocks production of HCl
Other Problems with Digestion Malabsorption (small intestine) eg Celiac’s disease = an autoimmune disease People do not spend enough time on digestion and absorption Many drugs cause acid production: coffee, tea, coke, alcohol, heart medicine Antibiotics can kill the “good” bacteria in the large intestine