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Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Christopher D. Lindsay, Christopher Green,

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Presentation on theme: "Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Christopher D. Lindsay, Christopher Green,"— Presentation transcript:

1 Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Christopher D. Lindsay, Christopher Green, Mike Bird, James T. A. Jones, James R. Riches, Katherine K. McKee, Mark S. Sandford, Debra A. Wakefield, and Christopher M. Timperley R. Soc. Open Sci. Volume 2(1):140160 January 28, 2015 ©2015 by Royal Society

2 Compounds of interest. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2:140160 ©2015 by Royal Society

3 Relationship of structure to hTRPA1 activation. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2:140160 ©2015 by Royal Society

4 hTRPA1 agonist potency correlates with irritancy to humans. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2:140160 ©2015 by Royal Society

5 CR and CS react reversibly with N-acetyl-l-cysteine methyl ester in CDCl3. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2:140160 ©2015 by Royal Society

6 Reactivity of BMNs to thiols. Christopher D. Lindsay et al. R. Soc. open sci. 2015;2:140160 ©2015 by Royal Society


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