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Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical.

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Presentation on theme: "Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical."— Presentation transcript:

1 Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis by Helen D. Donoghue, Oona Y.-C. Lee, David E. Minnikin, Gurdyal S. Besra, John H. Taylor, and Mark Spigelman Proceedings B Volume 277(1678):51-56 January 7, 2010 ©2010 by The Royal Society

2 The original appearance of the Granville mummy. Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56 ©2010 by The Royal Society

3 Demonstration of M. tuberculosis complex DNA in mummy lung sample. Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56 ©2010 by The Royal Society

4 Detection of M. tuberculosis complex mycolic acid PBA–PFB derivatives by reverse-phase fluorescence HPLC, from the Granville mummy femur and lung samples, in comparison with a known standard strain of M. tuberculosis. Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56 ©2010 by The Royal Society

5 Normal-phase HPLC analyses of the collected total mycolates from the reverse-phase separation, from the Granville mummy femur and lung samples, in comparison with a known standard strain of M. tuberculosis. Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56 ©2010 by The Royal Society

6 Reverse-phase HPLC analyses of the collected fractions from the normal-phase HPLC separation, from the Granville mummy femur and lung samples, in comparison with a known standard strain of M. tuberculosis. Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56 ©2010 by The Royal Society


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