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Plasma cell neoplasm Plasma cell Ig M component, para protein Monoclonal gammopathy
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Multiple Myeloma Bone marrow based Median age 70 Multifocal, bone, tumor masses Serum paraprotein, Urine Bence-Jones protein Osteolytic lesions, bone pain, hyper calcemia, anemia Renal failure
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Morphology –Increased plasma cells ( mature, immature and anaplastic) –Mass of plasma cells –Ig inclusions Immuno: CD20 neg, cytoplasmic Ig IgG>IgA
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Lambda
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Plasmacytoma Localized osseous or extra osseous plasma cell tumor
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kappa
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Monoclonal Gammopathy of Undetermined Significance MGUS Asymptomatic M protein (less than myeloma) BM Plasmacytosis <10% 25% progress to Multiple Myeloma
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Lymphoplasmacytic lymphoma B cell lymphoma Leukemic with bone marrow involvement Low grade Paraprotein IgM Waldensrom macroglobulinemia
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