1. CELL an interdisciplinary investigation into adult stem cell behaviour Mark d’Inverno dinverno@gold.ac.uk Goldsmiths College University of London

2. The CELL Project Wellcome Trust Jane Prophet Neil Theise Mark d’Inverno Rob Saunders Peter Ride

3. Traditional View of Cell Lineages Stem Cell Differentiated Cell

4. A New View of Cell Lineages Stem Cell Differentiated Cell

5. Computational Agents Autonomous Agents require no intervention Agents create their own goals Situated, embodied, sensitive and active Agents sense their environment Agents act upon their environment Interactive Agents interact with other agents

7. Problems for Stem Cell Researchers Problems performing experiments Impossible to track stem cells in the body Slides are manipulated images of dead tissue Experiments can only reveal one fate Problems working in the field of research Little consensus on basic terms Poor conceptual modelling

8. Agent-based Simulations consistent with lab - predictions biological intuitive visualisation is trojan horse conceptual framework aunt sally Towards tool for biologists DEMO Circular NicheLinear Niche

9. CELL - role of artists Staining Space by Jane Prophet

10. Biologists reaction to Model Nature “Cells fulfil all the criteria necessary to be considered agents within a complex system... they self-organize with external planning. What emerges...” Now you see it, now you don’t. Neil D. Theise Nature 435, 1165, 2005 interdisciplinary research?

11. Research Cluster interdisciplinary.co.uk UK-based IR community centred on design why, when, how and who? funded jointly by arts and science research councils theory/practice academic/commercial agents as metaphor and language for interdisciplinary design process based

13. Reflections language personal qualities social engineering teams responsibility map IR process re-negotiate goals evaluating creativity and innovation discipline change Goldsmiths Digital Studios

14. Thanks Neil Theise Jane Prophet Peter Ride Mark Kirkland Jon McCormack Alan Dorin Ingo Roeder’s Group Dave Winkler’s Group University of Westminster Wellcome Trust AHRB EPSRC British Academy HEFC